Adaptive hybrid acquisition of PN sequences forDS/SS communications

Kim, Chang Joo; Lee, Dong Doo; Hwang, Tae Won; Lee, Hyuck Jae; Lee, Hwang Soo

doi:10.1049/el:19980652

Cited by 11 publications

(3 citation statements)

References 4 publications

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“…For a reliable comparison, the same conditions are considered. Noting that the OSHAP is the hybrid version of the OSAP processor [14], formerly designed for serial search. In the other hand, we recall that the OSAP uses the kth smallest value, among the M available cells, as a power level estimate.…”

Section: Numerical Resultsmentioning

confidence: 99%

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Adaptive Hybrid Acquisition of PN Sequences Based on Automatic Multipath Cancellation in Frequency-Selective Rayleigh Fading Channels

Hacini

Farrouki

Hammoudi

2010

Wireless Pers Commun

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A hybrid PN-code acquisition scheme is proposed and studied for direct sequence code division multiple access communications in frequency-selective Rayleigh fading channels. The most important feature of the proposed system is its ability to dynamically estimate the number of multipath signals that may lie in the reference channel. The basic idea of the considered algorithm is to sort the partial correlations and carry out successive censoring tests by updating the noise estimation until the first path synchronization. Exact expressions for the probability of false alarm and the mean acquisition time are derived. The performances of the proposed system are then studied and compared with those of the adaptive hybrid acquisition processor (AHAP) and the ordered statistic hybrid acquisition processor (OSHAP). The effects of various channel parameters on the acquisition performance, namely the number of resolvable paths, the multipath intensity profile and the signal-to-noise ratio are also investigated. Numerical results show that the proposed acquisition scheme outperforms the conventional ones which are based on AHAP and OSHAP algorithms.

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Section: Numerical Resultsmentioning

confidence: 99%

“…processor (AHAP), has been used for a hybrid search systems [16]. Noting also that the AHAP processor has been extended to the case of antenna diversity in multipath situations [17].…”

mentioning

confidence: 99%

Adaptive Hybrid Acquisition of PN Sequences Based on Automatic Multipath Cancellation in Frequency-Selective Rayleigh Fading Channels

Hacini

Farrouki

Hammoudi

2010

Wireless Pers Commun

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“…Sildenafil exhibits near-complete systemic delivery (Hong et al , 2017), and in circulation it undergoes hepatic modification into desmethyl-sildenafil that retains some bioactivity (Kim et al, 2003). The prominent desmethyl-sildenafil peak in the MS/MS ion spectrum is due to the ionization energy as it was not detected in the liquid chromatography elution profile using pure compound, or in the plasma from malonyl-sildenafil treated mice (not shown).…”

Section: Discussionmentioning

confidence: 98%

A non-systemic phosphodiesterase-5 inhibitor suppresses colon proliferation in mice

Lee

Lebedyeva

Zhi

et al. 2022

Preprint

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Background and Purpose: Phosphodiesterase-5 inhibitors (PDE5i) are under investigation for repurposing as an intervention for colon cancer prevention. A drawback to conventional PDE5i are side-effects and drug-drug interactions that would be poorly tolerated when taken on a chronic basis for prevention. Experimental Approach: We designed an analog of the prototypical PDE5i sildenafil by replacing the methyl group on the piperazine ring with malonic acid to reduce lipophilicity and measured its entry into the circulation and effects on colon epithelium. Key Results: This modification did not affect pharmacology as malonyl-sildenafil had a similar IC50 to sildenafil (6.5 nM vs 7.5 nM respectively) but exhibited almost 100-fold reduced cell entry compared to sildenafil. Using an LC-MS/MS approach, doses of malonyl-sildenafil up to 36 mg/kg were barely detectable in mouse plasma after oral administration but was detected at high levels in the feces. This contrasted with sildenafil that was detected in the plasma but not in the feces. No bioactive metabolites of malonyl-sildenafil were detected in the circulation by measuring interactions with isosorbide mononitrate. Treatment of mice with malonyl-sildenafil in the drinking water for 8 days was well-tolerated and resulted in a suppression of proliferation in the colon epithelium that is consistent with results published previously for mice treated with PDE5i. Conclusion and Implications: A carboxylic acid-containing analog of sildenafil prohibits systemic delivery of the compound but maintains sufficient penetration into the colon epithelium to suppress proliferation. This highlights a novel approach to generate a first in class drug for colon cancer chemoprevention.

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PN code acquisition using smart antennas and adaptive thresholding for spread spectrum communications

2015

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Adaptive hybrid acquisition of PN sequences forDS/SS communications

Cited by 11 publications

References 4 publications

Adaptive Hybrid Acquisition of PN Sequences Based on Automatic Multipath Cancellation in Frequency-Selective Rayleigh Fading Channels

Adaptive Hybrid Acquisition of PN Sequences Based on Automatic Multipath Cancellation in Frequency-Selective Rayleigh Fading Channels

A non-systemic phosphodiesterase-5 inhibitor suppresses colon proliferation in mice

PN code acquisition using smart antennas and adaptive thresholding for spread spectrum communications

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