Adaptive immunity is severely impaired by open-heart surgery

Sano, Tetsuro; Morita, Shigeki; Tominaga, Ryuji; Masuda, Mitsuharu; Tomita, Yukihiro; Yasutsune, Toru; Yasui, Hirofumi

doi:10.1007/bf03032286

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…1 An open heart surgery, which is associated with the usage of CPB, has been reported to cause an in vitro temporary cellular immune depression, which is most pronounced in the first 2 days after surgery, may last for about 2 weeks, and is manifested by an in vitro attenuated lymphocytes response to mitogens, as well as change in T cell subpopulations. [4][5][6][7][8][9] Sano et al, 4 examined lymphocyte proliferation in vitro, after incubation with PPD antigen, in adults undergoing open heart surgery. They found that in the first 2 days after surgery the amount of lymphocytes proliferation was only 3.2% of the presurgical response.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Open Heart Surgery on Tuberculin Skin Test Reactivity

Stein

Sela‐Razon

Linder

et al. 2007

Annals of the New York Academy of Sciences

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To examine whether treatment with cardiopulmonary bypass (CPB), which causes transient cellular immunity depression, influences tuberculin skin testing (TST) interpretation. The study was also aimed to assess the degree of cellular immunity depression following open heart surgery. Fifteen children from developing countries with latent tuberculosis (TST >or=10 mm), undergoing open heart surgery had their TST repeated within 48-72 h following surgery. We compared the size of skin test induration before and after surgery and the relation of postsurgery skin induration to time on CPB (pump time). There was no significant difference in the size of induration before and after surgery (mean: 14.7 mm versus 13 mm, respectively). Pump time ranged from 38 to 204 min (mean: 110 min). Two of the children had pump time over 3 h. The TST of both of them turned negative after surgery, as opposed to all other children (P = 0.01). Most patients retained skin test reactivity. Only patients with pump time longer than 3 h had a negative TST.

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Section: Discussionmentioning

confidence: 99%

The Effect of Open Heart Surgery on Tuberculin Skin Test Reactivity

Stein

Sela‐Razon

Linder

et al. 2007

Annals of the New York Academy of Sciences

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Prostaglandin el attenuates impairment of cellular immunity after cardiopulmonary bypass

Sano

Masuda

Morita

et al. 2006

Jpn J Thorac Caridovasc Surg

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Cardiopulmonary bypass, steroid administration, and surgical injury synergistically impair memory T cell function and antigen presentation

Sano

Morita

Masuda

et al. 2003

Interactive Cardiovascular and Thoracic Surgery

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Previous reports showed that cardiac surgery with cardiopulmonary bypass (CPB) impair cell-mediated immunity by using antigen-non-specific responses. This study elucidated the effects of cardiac surgery with CPB on antigen-specific immunity. Twenty patients who underwent elective cardiac surgery using CPB were randomly divided into two groups: group A (n=10) and group B (n=10) with and without steroid administration, respectively. Group C patients underwent off-pump CABG (n=8). Peripheral blood mononuclear cells (PBMCs) were taken before and after surgery. Proliferation responses to pure protein derivative antigen were measured. The effects of CPB and steroid on T cell response and antigen-presentation were assessed by cross-stimulation between the preoperative and the postoperative PBMCs. Antigen-specific T cell responses decreased to about 5% of the preoperative values immediately after surgery with CPB, regardless of steroid administration. The T cell response in group B on POD 7 was significantly higher than that in group A. CPB impaired mainly T cell responses, and steroid administration enhanced impairment of T cell response and antigen-presentation. Open-heart surgery with CPB severely impaired antigen-specific immunity. Steroid administration enhanced the impairment of antigen-presentation as well as T cell function, and retarded the recovery of antigen-specific immunity.

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Adaptive immunity is severely impaired by open-heart surgery

Cited by 4 publications

References 16 publications

The Effect of Open Heart Surgery on Tuberculin Skin Test Reactivity

The Effect of Open Heart Surgery on Tuberculin Skin Test Reactivity

Prostaglandin el attenuates impairment of cellular immunity after cardiopulmonary bypass

Cardiopulmonary bypass, steroid administration, and surgical injury synergistically impair memory T cell function and antigen presentation

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