Adaptive Iterative Dose Reduction in coronary CT angiography using 320-row CT: Assessment of radiation dose reduction and image quality

Tomizawa, Nobuo; Nojo, Takeshi; Akahane, Masaaki; Torigoe, Rumiko; Kiryu, Shigeru; Ohtomo, Kuni

doi:10.1016/j.jcct.2012.02.009

Cited by 50 publications

(29 citation statements)

References 17 publications

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“…Specifically, measurements with the 320 row detector CT were performed with the MOSFET detectors on top of the phantom surface, whereas Hurwitz et al ., obtained measurements within the phantom and more closely simulated the anatomic position of the thyroid gland, thus resulting in less scatter and more dose absorption of interposed tissue and hence lower absorbed dose readings of the detectors. [20] However, thyroid dose absorptions are negligibly low in both studies, and the dose that is absorbed by the thyroid gland in association with CCTA can be safely considered as clinically inconsequential as the likelihood of cancer induction is close to zero based on BEIR VII data for patients between the ages of 50-70 years.…”

Section: Discussionmentioning

confidence: 99%

Cancerogenesis Risks between 64 and 320 Row Detector CT for Coronary CTA Screening

Khan

Khosa

Nikolic

et al. 2014

Journal of Clinical Imaging Science

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Objectives:This study compares cancerogenesis risks posed by the 64 row detector and the 320 row detector computed tomography scanners used during coronary computed tomography angiography (CCTA) following decennial screening guidelines.Material and Methods:Data of the radiation absorbed after CCTA by lung, thyroid, and female breast in patients between 50 and 70 years of age obtained from prior published literature for the 64 row CT scanner were compared with data from our study using 320 row detector CT scanner. Data from the 64 row and the 320 row detector CT scanners was used to determine lifetime attributable risks (LAR) of cancer based on the biological effects of ionizing radiation (BEIR) VII report.Results:The relative reduction of LAR (%) for 50-, 60-, and 70-year-old patients undergoing scanning with the 320 row detector CT scanner was 30% lower for lung, and more than 50% lower for female breast when compared with results from 64 row detector CT scanner. The use of 320 row detector CT would result in a combined cumulative cancer incidence of less than 1/500 for breast in women and less than 1/1000 for lung in men; By comparison, this is much lower than other more common risk factors: 16-fold for lung cancer in persistent smokers, 2-fold for breast cancer with a first degree family member history of breast cancer, and 10-fold for thyroid cancer with a family member with thyroid cancer. Decennial screening would benefit at least 355,000 patients from sudden cardiac death each year, 94% of whom have significant coronary artery disease, with at least one stenosis >75%. LAR for thyroid cancer was negligible for both scanners.Conclusion:Lung and female breast LAR reductions with 320 row detector compared with 64 row detector CT are substantial, and the benefits would outweigh increased cancer risks with decennial screening in the age group of 50-70 years.

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Section: Discussionmentioning

confidence: 99%

Cancerogenesis Risks between 64 and 320 Row Detector CT for Coronary CTA Screening

Khan

Khosa

Nikolic

et al. 2014

Journal of Clinical Imaging Science

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“…In three studies, the effective dose was (re)calculated using the DLP, because the effective dose was not provided or calculated with a different conversion factor. 16,18,20 The pooled routine effective dose using FBP was 4.2 (95% CI 3.5-5.0) mSv. At reduced dose level using IR, the pooled effective dose was 2.2 (95% CI 1.3-3.1) mSv (Figure 2).…”

Section: Study Characteristicsmentioning

confidence: 98%

Dose reduction with iterative reconstruction for coronary CT angiography: a systematic review and meta-analysis

Harder

Willemink

Ruiter

et al. 2016

BJR

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Objective: To investigate the achievable radiation dose reduction for coronary CT angiography (CCTA) with iterative reconstruction (IR) in adults and the effects on image quality. Methods: PubMed and EMBASE were searched, and original articles concerning IR for CCTA in adults using prospective electrocardiogram triggering were included. Primary outcome was the effective dose using filtered back projection (FBP) and IR. Secondary outcome was the effect of IR on objective and subjective image quality. Results: The search yielded 1616 unique articles, of which 10 studies (1042 patients) were included. The pooled routine effective dose with FBP was 4.2 mSv [95% confidence interval (CI) 3.5-5.0]. A dose reduction of 48% to a pooled effective dose of 2.2 mSv (95% CI 1.3-3.1) using IR was reported. Noise, contrast-to-noise ratio and subjective image quality were equal or improved in all but one study, whereas signal-to-noise ratio was decreased in two studies with IR at reduced dose. Conclusion: IR allows for CCTA acquisition with an effective dose of 2.2 mSv with preserved objective and subjective image quality. INTRODUCTIONThe number of CT examinations has increased rapidly over the past decades leading to increased radiation exposure.

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“…Observational studies after implementation of ASIR have demonstrated 44-54 % reductions in effective dose [18, 34 • ]. AIDR has shown improved subjective and objective image quality with simulated 50 % dose reduction compared with full-dose FBP reconstructions of the same data [38], and one observational study demonstrated dose savings of 22 % without compromising quality [31]. Low-dose acquisitions using IRIS have demonstrated improved image quality compared with routine acquisitions using FBP with dose savings up to 62 % [27 • ].…”

Section: Noise and Radiation Dose Reductionmentioning

confidence: 99%

The Role of Iterative Reconstruction Techniques in Cardiovascular CT

2013

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Iterative reconstruction (IR) techniques for cardiovascular computed tomography (CT) have enjoyed a resurgence of interest in recent years as computer power has increased enough to enable reasonably timely reconstructions. The major purported benefit of current IR techniques involves image noise reduction, which both provides improved image quality and enables radiation dose reductions. Several widely available products have been released by the major CT vendors that vary in their underlying techniques but, according to the current literature, give similar results. Future algorithms should both refine current IR techniques and expand the role of IR to additional cardiovascular CT applications. This review examines the technical basis of IR, the IR products available commercially, the current data on IR in cardiovascular CT, and the future directions of the field.

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Adaptive Iterative Dose Reduction in coronary CT angiography using 320-row CT: Assessment of radiation dose reduction and image quality

Cited by 50 publications

References 17 publications

Cancerogenesis Risks between 64 and 320 Row Detector CT for Coronary CTA Screening

Cancerogenesis Risks between 64 and 320 Row Detector CT for Coronary CTA Screening

Dose reduction with iterative reconstruction for coronary CT angiography: a systematic review and meta-analysis

The Role of Iterative Reconstruction Techniques in Cardiovascular CT

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