The topic of adaptive event‐triggered control for multi‐input‐multi‐output nonlinear systems with asymmetric state constraints is considered in this article. First, by introducing unified barrier functions method, the initial system is transformed to a non‐constraints system, which brings that the requirement of feasibility conditions could be eliminated and the constraint functions could be relaxed effectively. Then, an adaptive tracking controller is designed by combining some excellent technology, where command filter is utilized to overcome the explosion of complexity, neural network is introduced to approximate unknown nonlinear function, and event‐triggered mechanism is proposed to save communication resources. The designed control scheme can make the outputs of the system to track the target trajectories within a small bounded error range, all signals in the closed‐loop system are bounded, and all states do not escape the state constraints. Finally, practical and comparative examples are given to verify the effectiveness of the method.