Due to handover failure, call drop occurs frequently. When a large number of incoming and handoff calls arrive at the same time, the performance of the conventional handoff algorithms may fall down. Moreover, multiple factors such as signal quality and available channels of cellular network can’t be evaluated in conventional algorithms. When mobile station (MS) moves, the connection of MS with nearby base station (BS) has to be switched from one to adjacent station. In this case, unnecessary handoffs will be occurred due to lack of proper decision of handoffs or lack of consideration about signal quality with available free channels. As a result call drop will occur frequently. For performing handoff efficiently, fuzzy logic based handoff decision algorithm, adaptive handoff threshold level using neural network and priority based dynamic channel allocation algorithm using neuro-fuzzy system has been proposed in this work. These algorithms will mainly focus on the proper decision of handoff based on evaluating signal strength, available free channels, spectrum efficiency, MS speed and distance from BS so that unnecessary and inefficient handoffs can’t be performed. Simulation revealed that using neuro-fuzzy system, the channel capacity, SIR and Handoff management were improved better than the others in terms of spectrum utilization efficiency, MS speed and SIR. The efficacy of the methodology has been proved by imitating the proposed model using MATLAB software.