Adaptive optics imaging in the most common inherited retinal degenerations

Samelska, Katarzyna; Kupis, Magdalena; Zaleska-Żmijewska, Anna; Szaflik, Jacek P.

doi:10.5114/ko.2021.107769

Cited by 2 publications

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“…Adaptive optics (AO) is an imaging technique originally developed for precise visualization in astronomy, capable of correcting atmospheric irregularities. This aberration-correcting system provided high-quality imaging of distant objects [40,41]. In 1989, Dreher et al [42] developed improvements in laser scanning tomography, enabling the compensation of corneal and lens aberrations to assess the retinal nerve fiber layer (RNFL) thickness and optic disc topography of the human eye.…”

Section: Adaptive Opticsmentioning

confidence: 99%

Characteristics of Rare Inherited Retinal Dystrophies in Adaptive Optics—A Study on 53 Eyes

Samelska,

Szaflik,

Guszkowska

et al. 2023

Diagnostics

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Inherited retinal dystrophies (IRDs) are genetic disorders that lead to the bilateral degeneration of the retina, causing irreversible vision loss. These conditions often manifest during the first and second decades of life, and their primary symptoms can be non-specific. Diagnostic processes encompass assessments of best-corrected visual acuity, fundoscopy, optical coherence tomography, fundus autofluorescence, fluorescein angiography, electrophysiological tests, and genetic testing. This study focuses on the application of adaptive optics (AO), a non-invasive retinal examination, for the assessment of patients with IRDs. AO facilitates the high-quality, detailed observation of retinal photoreceptor structures (cones and rods) and enables the quantitative analysis of parameters such as cone density (DM), cone spacing (SM), cone regularity (REG), and Voronoi analysis (N%6). AO examinations were conducted on eyes diagnosed with Stargardt disease (STGD, N=36), cone dystrophy (CD, N=9), and cone-rod dystrophy (CRD, N=8), and on healthy eyes (N=14). There were significant differences in the DM, SM, REG, and N%6 parameters between the healthy and IRD-affected eyes (p<0.001 for DM, SM, and REG; p=0.008 for N%6). The mean DM in the CD, CRD, and STGD groups was 8900.39/mm2, 9296.32/mm2, and 16,209.66/mm2, respectively, with a significant inter-group difference (p=0.006). The mean SM in the CD, CRD, and STGD groups was 12.37 μm, 14.82 μm, and 9.65 μm, respectively, with a significant difference observed between groups (p=0.002). However, no significant difference was found in REG and N%6 among the CD, CRD, and STGD groups. Significant differences were found in SM and DM between CD and STGD (p=0.014 for SM; p=0.003 for DM) and between CRD and STGD (p=0.027 for SM; p=0.003 for DM). Our findings suggest that AO holds significant potential as an impactful diagnostic tool for IRDs.

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Section: Adaptive Opticsmentioning

confidence: 99%

Characteristics of Rare Inherited Retinal Dystrophies in Adaptive Optics—A Study on 53 Eyes

Samelska,

Szaflik,

Guszkowska

et al. 2023

Diagnostics

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“…Adaptive optics (AO) is an imaging technique initially developed for precise visualisation in astronomy, where it corrected atmospheric irregularities. The aberration-correcting system provides high-quality imaging of distant objects [ 11 , 12 ]. This high-quality visualisation is used in ophthalmology to evaluate the microstructures of the human retina with the precision to visualise a single cell.…”

Section: Introductionmentioning

confidence: 99%

Progression of Rare Inherited Retinal Dystrophies May Be Monitored by Adaptive Optics Imaging

Samelska,

Szaflik,

Śmigielska

et al. 2023

Life

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Inherited retinal dystrophies (IRDs) are bilateral genetic conditions of the retina, leading to irreversible vision loss. This study included 55 eyes afflicted with IRDs affecting the macula. The diseases examined encompassed Stargardt disease (STGD), cone dystrophy (CD), and cone–rod dystrophy (CRD) using adaptive optics (Rtx1™; Imagine Eyes, Orsay, France). Adaptive optics facilitate high-quality visualisation of retinal microstructures, including cones. Cone parameters, such as cone density (DM), cone spacing (SM), and regularity (REG), were analysed. The best corrected visual acuity (BCVA) was assessed as well. Examinations were performed twice over a 6-year observation period. A significant change was observed in DM (1282.73/mm2 vs. 10,073.42/mm2, p< 0.001) and SM (9.83 μm vs. 12.16 μm, p< 0.001) during the follow-up. BCVA deterioration was also significant (0.16 vs. 0.12, p = 0.001), albeit uncorrelated with the change in cone parameters. No significant difference in REG was detected between the initial examination and the follow-up (p = 0.089).

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Adaptive optics imaging in the most common inherited retinal degenerations

Cited by 2 publications

References 0 publications

Characteristics of Rare Inherited Retinal Dystrophies in Adaptive Optics—A Study on 53 Eyes

Characteristics of Rare Inherited Retinal Dystrophies in Adaptive Optics—A Study on 53 Eyes

Progression of Rare Inherited Retinal Dystrophies May Be Monitored by Adaptive Optics Imaging

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