Targeting at the improvement and optimization of the deficiencies of traditional over-current protection, multi-agent strategy is applied in relay protection to improve the fast response of the backup protection. While confirming the feasibility of the above-mentioned strategy, PLC and field bus techniques are adopted to realize information interaction and liaison among multiple agents and host computer in the environment, converting the original passive time-limit mechanism to active strategic collaboration. And the thesis materializes the effective application of the microcomputer-based, multi-agent-based protection in specific projects.