Adaptive plasticity of natural interleukin-35-induced regulatory T cells (Tr35) that are required for T-cell immune regulation
Xundong Wei,
Jianhua Zhang,
Jian Cui
et al.
Abstract:Background:
IL-35 potently inhibits immune responses both
in vivo
and
in vitro
. However, the specific characteristics of IL-35-producing cells, including their developmental origin, cellular phenotype, and function, are unknown.
Methods:
By using a novel IL-35 reporter mouse (Ebi3-Dre-Thy1.1) and double transgenic fate-mapping reporter mice (35EbiT-Rosa26-rox-tdTomato reporter mice or Foxp3 fate-mapping system), we tracked and an… Show more
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