Adaptive remodeling of the infarct-related artery is associated with recurrent ischemic events after thrombolysis in acute myocardial infarction

Abstract

Adaptive remodeling of the infarct-related artery is associated with early postinfarction angina pectoris after thrombolysis of AMI.

Impact of arterial remodelling and plaque rupture on target and non-target lesion revascularisation after stent implantation in patients with acute coronary syndrome: an intravascular ultrasound study

“…Our present result, showing that PR is related to unfavourable clinical outcome following PCI, is in concordance with previous studies on patients with angina pectoris 4–6 9. Although one study has shown the possible relationship between pre-intervention remodelling and recurrence after thrombolysis in patients with AMI,10 our results further suggest that, even after stenting, patterns of remodelling have an impact on prognosis in patients with ACS.…”

Caracterização Morfológica e Tecidual de Lesões Culpadas em Pacientes com Infarto Agudo do Miocárdio com Supradesnivelamento do Segmento ST Após Uso de Fibrinolítico. Análise com Ultrassom Intracoronário e Tecnologia iMAP®

“…16,18 One of the most often studied findings associated with plaque vulnerability is arterial remodeling. Initially described by Glagov et al 19 in 1987, the positive arterial remodeling has been observed in atherosclerotic plaques responsible for acute coronary events, 6,20,21 and is associated with the increase in CK-MB after PCI, 22 no-reflow phenomena during primary PCI, 23 recurrent ischemia after PCI, 24 major cardiovascular events in patients with unstable angina undergoing any form of revascularization, 25 and intimal hyperplasia after PCI with bare-metal 26 and drug-eluting stents. 27 In the present study, the mean arterial-remodeling index was 1.4 ± 1.0, greater than 1.05, thus characterizing the predominance of positive arterial remodeling and corroborating the aforementioned literature.…”

Biphasic release of protein from polyethylene glycol and polyethylene glycol/modified dextran microspheres

“…Administration of a ''clot-busting'' drug or plasminogen activator (PA) can break up the clot and restore flow with proven efficacy in saving lives and reducing morbidity if applied in a timely manner. 1,2 However, reocclusion of coronary arteries after thrombolytic therapy occurs in 7-32% of patients 3 and increases the level of mortality. 4 The mechanism of reocclusion is obscure but it may be due to multiple factors including thrombi traveling downstream, the release of various chemicals that cause restenosis due to spasm of the blood vessel or the exposure of active surface that initiates platelet response.…”