Developing universal stimuli‐responsive materials capable of emitting a broad spectrum of colors is highly desirable. Herein, we deliberately grafted a conformation‐adaptable organic chromophore into the established coordination space of a flexible metal–organic framework (MOF). In terms of the coupled structural transformations and the space confinement, the chromophore in the MOF matrix underwent well‐regulated conformational changes under physical and chemical stimuli, simultaneously displaying thermo‐, piezo‐, and solvato‐fluoro‐chromism with color tunability over the visible range. Owing to the resilient nature and the reduced dimensionality of the selected coordination space, all three color modulations behaved in a sensitive and self‐reversible manner, each following a linear correlation of the emission maximum with stimulus. Single‐crystal X‐ray diffraction of the variable‐temperature structures and solvent‐inclusion crystals elucidated the intricate color varying mechanisms.