Adaptive response to 2 low doses of X-rays in human blood lymphocytes

Fan, Saijun; Vijayalaxmi, .; Mindek, G.; Burkart, W.

doi:10.1016/0165-7992(90)90122-z

Cited by 35 publications

(6 citation statements)

References 11 publications

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“…Cells exposed to a small, initial priming dose of radiation incurred less overall damage when given a subsequent, larger, challenge dose, is classed as an AR. This effect has been documented with multiple agents including [ 3 H] thymidine, 26 low-dose X-ray radiation, 27 and is thought to be dependent on the dose and type of radiation as well as the timing between exposures. 28 Human lymphocytes have been previously used to study induced ARs.…”

Section: Discussionmentioning

confidence: 99%

Biological Response of Positron Emission Tomography Scan Exposure and Adaptive Response in Humans

et al. 2015

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The biological effects of exposure to radioactive fluorodeoxyglucose (18F-FDG) were investigated in the lymphocytes of patients undergoing positron emission tomography (PET) procedures. Low-dose, radiation-induced cellular responses were measured using 3 different end points: (1) apoptosis; (2) chromosome aberrations; and (3) γH2AX foci formation. The results showed no significant change in lymphocyte apoptosis, or chromosome aberrations, as a result of in vivo 18F-FDG exposure, and there was no evidence the PET scan modified the apoptotic response of lymphocytes to a subsequent 2 Gy in vitro challenge irradiation. However, lymphocytes sampled from patients following a PET scan showed an average of 22.86% fewer chromosome breaks and 39.16% fewer dicentrics after a subsequent 2 Gy in vitro challenge irradiation. The effect of 18F-FDG exposure on phosphorylation of histone H2AX (γH2AX) in lymphocytes of patients showed a varied response between individuals. The relationship between γH2AX foci formation and increasing activity of 18F-FDG was not directly proportional to dose. This variation is most likely attributed to differences in the factors that combine to constitute an individual’s radiation response. In summary, the results of this study indicate18F-FDG PET scans may not be detrimental but can elicit variable responses between individuals and can modify cellular response to subsequent radiation exposures.

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Section: Discussionmentioning

confidence: 99%

Biological Response of Positron Emission Tomography Scan Exposure and Adaptive Response in Humans

et al. 2015

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“…Such proteins involved in DNA repair as DNA-PK, ATM, TP53 and poly (ADP-ribose) polymerase (PARP) have been proposed to participate in adaptive response [30,31]. The change in chromatin conformation could protect DNA against indirect effects of challenging dose in two ways; either through folding of the chromatin into a higher-ordered structure that makes it less accessible to damaging factors [32] or by increasing the accessibility of damaged sites to repair enzymes [33].…”

Section: Discussionmentioning

confidence: 99%

Studies of adaptive response and mutation induction in MCF-10A cells following exposure to chronic or acute ionizing radiation

Manesh

Sangsuwan

Wójcik

et al. 2015

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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“…They found that the time delay between doses can change Table 3 The source data used for estimation of α 0 , α 1 and α 2 parameters, selected for DNA mutations, based on studies by Day et al (2006Day et al ( , 2007 the shape of the survival curve of irradiated cells but both doses were large and no low conditioning dose was tested. Important changes appeared in 1980s and 1990s, when many studies began reporting that the radiation adaptive response effect showed strong results with a low priming dose and high challenging dose scheme (Olivieri et al 1984;Shadley and Dai 1992;Yonezawa et al 1990;Fan et al 1990;Liu et al 1992;Farooqi and Kesavan 1993;Cai et al 1994). In the 1990s, this special case of adaptive response was called the priming dose effect or, a few years later, the Yonezawa effect (Wang et al 2013(Wang et al , 2018(Wang et al , 2021Liu et al 2019).…”

Section: Discussionmentioning

confidence: 99%

The radiation adaptive response and priming dose influence: the quantification of the Raper–Yonezawa effect and its three-parameter model for postradiation DNA lesions and mutations

Fornalski

Adamowski

Dobrzyński

et al. 2022

Radiat Environ Biophys

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The priming dose effect, called also the Raper–Yonezawa effect or simply the Yonezawa effect, is a special case of the radiation adaptive response phenomenon (radioadaptation), which refers to: (a) faster repair of direct DNA lesions (damage), and (b) DNA mutation frequency reduction after irradiation, by applying a small priming (conditioning) dose prior to the high detrimental (challenging) one. This effect is observed in many (but not all) radiobiological experiments which present the reduction of lesion, mutation or even mortality frequency of the irradiated cells or species. Additionally, the multi-parameter model created by Dr. Yonezawa and collaborators tried to explain it theoretically based on experimental data on the mortality of mice with chronic internal irradiation. The presented paper proposes a new theoretical approach to understanding and explaining the priming dose effect: it starts from the radiation adaptive response theory and moves to the three-parameter model, separately for two previously mentioned situations: creation of fast (lesions) and delayed damage (mutations). The proposed biophysical model was applied to experimental data—lesions in human lymphocytes and chromosomal inversions in mice—and was shown to be able to predict the Yonezawa effect for future investigations. It was also found that the strongest radioadaptation is correlated with the weakest cellular radiosensitivity. Additional discussions were focussed on more general situations where many small priming doses are used.

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Adaptive response to 2 low doses of X-rays in human blood lymphocytes

Cited by 35 publications

References 11 publications

Biological Response of Positron Emission Tomography Scan Exposure and Adaptive Response in Humans

Biological Response of Positron Emission Tomography Scan Exposure and Adaptive Response in Humans

Studies of adaptive response and mutation induction in MCF-10A cells following exposure to chronic or acute ionizing radiation

The radiation adaptive response and priming dose influence: the quantification of the Raper–Yonezawa effect and its three-parameter model for postradiation DNA lesions and mutations

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