Adaptive User Interface (AUI) can change its layout, appearance, and/or elements based on the needs of its user requirements and current usage context. The AUIs are used in state-of-the-art software products, applications for mobile devices, and websites. Moreover, AUI is an emerging research field in a mobile context, as it can enhance usability, performance, and user satisfaction. This study aims to propose a conceptual framework for developing a real-time self-adaptive user interface based on the Android Operating System (OS). Furthermore, the focus is on developing the core algorithms for the modules of the proposed framework. To evaluate the performance of the proposed framework, three case studies have been designed based on the daily and weekly activities of the user. Moreover, an expert-based validation approach is employed to obtain the expert’s feedback regarding the proposed framework. The result indicates that the proposed framework helps improve user satisfaction and experience by making an intelligent mobile device interface. The results of the framework’s evaluation and validation show the proposed framework’s feasibility and effectiveness. We conclude that the current work is beneficial in filling the identified research gap. Moreover, this research shows the significance of an adaptive interface in an Android OS-based context. In addition, it not only helps in improving the user interest and satisfaction but also enhances the overall performance of the mobile device.