2013
DOI: 10.1101/gad.211649.112
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Adaptive thermogenesis in adipocytes: Is beige the new brown?

Abstract: One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat. In addition to classical brown adipose tissue, the last few years have seen great advances in our understanding of inducible thermogenic adipose tissue, also referred to as beige fat. A deeper understanding of the mol… Show more

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Cited by 744 publications
(692 citation statements)
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References 203 publications
(161 reference statements)
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“…Third, brown and beige adipocytes express distinct and distinguishing gene signatures 10,11 . Fourth, a striking difference between the two cell types is that brown adipocytes express high levels of Ucp1 and other thermogenic genes under basal (unstimulated) conditions, whereas beige adipocytes express these genes only in response to activators such as agonists of the β-adrenergic receptor or peroxisome proliferator-activated receptor-γ (Ppar-γ) 12,13 . Importantly, this trait is fat-cell autonomous, as brown fat cells increase their expression of thermogenic genes (for example, Ucp1) during adipogenesis in culture from preadipocytes without the addition of classical activators 14 .…”
Section: Volume 19 | Number 10 | October 2013 Nature Medicine R E V Imentioning
confidence: 99%
“…Third, brown and beige adipocytes express distinct and distinguishing gene signatures 10,11 . Fourth, a striking difference between the two cell types is that brown adipocytes express high levels of Ucp1 and other thermogenic genes under basal (unstimulated) conditions, whereas beige adipocytes express these genes only in response to activators such as agonists of the β-adrenergic receptor or peroxisome proliferator-activated receptor-γ (Ppar-γ) 12,13 . Importantly, this trait is fat-cell autonomous, as brown fat cells increase their expression of thermogenic genes (for example, Ucp1) during adipogenesis in culture from preadipocytes without the addition of classical activators 14 .…”
Section: Volume 19 | Number 10 | October 2013 Nature Medicine R E V Imentioning
confidence: 99%
“…This phenomenon is often referred to as the 'browning' of WAT. [11][12][13]15 Although cellular origins of beige adipocytes remain poorly understood, these cells in the epididymal WAT of rodents are derived through proliferation and differentiation of precursors that express PDGFRα (plateletderived growth factor receptor α) and SCA1 (spinocerebellar ataxia type 1). 16 A recent paper reported that~10% of the UCP1-positive beige adipocytes in inguinal WAT arise from smooth muscle precursors that express Myh11.…”
Section: Developmental Lineages Of Brown and Beige Adipocytes In Micementioning
confidence: 99%
“…Recent studies have shown that the browning of adipose tissue, including brown remodelling of WAT and promotion of the brown adipose tissue (BAT) function, could counteract obesity (reviewed in Bartelt and Heeren [10]). Brown remodelling of WAT confers BAT-like features onto WAT and remodels it to exert an energy-disposal capacity rather than just acting as an energy storage site (reviewed in Wu et al [11]). …”
Section: Introductionmentioning
confidence: 99%