We review the evolution of the nonparametric regression modeling in imaging from the local Nadaraya-Watson kernel estimate to the nonlocal means and further to transform-domain Þltering based on nonlocal block-matching. The considered methods are classiÞed mainly according to two main features: local/nonlocal and pointwise/multipoint. Here nonlocal is an alternative to local, and multipoint is an alternative to pointwise. These alternatives, though obvious simpliÞcations, allow to impose a fruitful and transparent classiÞcation of the basic ideas in the advanced techniques. Within this framework, we introduce a novel single-and multiplemodel transform domain nonlocal approach. The Block Matching and 3-D Filtering (BM3D) algorithm, which is currently one of the best performing denoising algorithms, is treated as a special case of the latter approach.