The analysis of the impact of video content and transmission impairments on Quality of Experience (QoE) is a relevant topic for the robust design and adaptation of multimedia infrastructures, services, and applications. The goal of this paper is to study the impact of video content on QoE for different levels of impairments. In more details, this contribution aims at i) the study of the impact of delay, jitter, packet loss, and bandwidth on QoE, ii) the analysis of the impact of video content on QoE, and iii) the evaluation of the relationship between content related parameters (spatial-temporal perceptual information, motion, and data rate) and the QoE for different levels of impairments.