We introduce a novel method of efficiently simulating the non-equilibrium steady state of large many-body open quantum systems with highly non-local interactions, based on a variational Monte Carlo optimization of a matrix product operator ansatz. Our approach outperforms and offers several advantages over comparable algorithms, such as an improved scaling of the computational cost with respect to the bond dimension for periodic systems. We showcase the versatility of our approach by studying the phase diagrams and correlation functions of the dissipative quantum Ising model with collective dephasing and long-ranged power law interactions for spin chains of up to N=100 spins.