Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of Spinacia oleracea L.

Sidorova, Yuliya S.; Шипелин, В А; Петров, Н. А.; Зорин, С Н; Мазо, В К

doi:10.3390/plants10122555

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…The predominant phenolic acids in spinach are ferulic acid and p-coumaric acid. In spinach leaves, the content of 20-hydroxyecdysone is about 0.01% (in terms of fresh weight), which is significantly lower than in medicinal plants [4].…”

Section: Introductionmentioning

confidence: 74%

Evaluation of the effectiveness of new inulin complexes with extracts from quinoa grains and spinach leaves

Sidorova,

Biryulina,

Petrov

et al. 2023

E3S Web of Conf.

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Consumption of plant-derived prebiotics can help reduce the body’s susceptibility to chronic fatigue syndrome, psycho-emotional stress, and the negative effects of increased physical and cognitive overloads. Inulin, a polysaccharide obtained from chicory roots, has beneficial effects on the intestinal microflora. It seems promising to combine inulin with functional ingredients from spinach leaves and quinoa grains. Spinach leaves contain biologically active substances such as carotenoids, phenolic compounds and flavonoids. Quinoa grains contain protein (12.9%), with a high content of lysine and methionine, are rich in fiber, minerals, more than 20 phenolic compounds have been identified in their composition, tannins, saponins, sterols, phytic acid and ecdysteroids are present in small quantities. The aim of this study was to evaluate the effectiveness and safety of the prophylactic administration of the developed complexes to the diet of experimental male Wistar rats. The experiment was carried out during 14 days. Consumption of spinach leaves extract and a complex of spinach extract with inulin by animals decreased the concentration of corticosterone in the blood while simultaneously increasing the content of prostaglandin E2. Consumption of quinoa grain extract and a complex of quinoa extract with inulin significantly reduced only blood corticosterone levels. The beneficial effects of the developed complexes with inulin on the intestinal microbiota have been shown.

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Section: Introductionmentioning

confidence: 74%

Evaluation of the effectiveness of new inulin complexes with extracts from quinoa grains and spinach leaves

Sidorova,

Biryulina,

Petrov

et al. 2023

E3S Web of Conf.

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“…The importance of adaptogens as regulators of homeostasis is significant. This is primarily due to increasing environmental pollution and urban stress, which lead to previously rare diseases [24]. Adaptogenic drugs enable a modern person to tolerate various external negative effects more easily, increasing his resistance to various extreme factors [25].…”

Section: Resultsmentioning

confidence: 99%

The study of the effect of drinks based on extracts of herbal adaptogens on the functional status of athletes during physical activity

Martazanova¹,

Maslova

Ulikhanov

et al. 2023

Potr. S. J. F. Sci.

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Adverse environmental factors, stress, lack of sleep and rest, and heavy physical exertion, deplete the human body. In particular, the reserves of the main metabolites, water, and oxygen, are very limited. People, especially athletes, need to take special dietary supplements with adaptogenic properties to adapt to stressful extreme loads. In this study, the influence of using extracts of leuzea, ginseng, and Eleutherococcus on athletes' performance, endurance, strength, and emotional state is carried out. The studies were conducted on four groups of male athletes aged from 19 to 25 years. For three weeks, diagnostics of vital lung capacity, Stange, and Genchi tests are carried out, and data on the general impressions of athletes are collected. According to the research results, the use of adaptogens leads to an increase in physical performance. After the first week of the study, a positive effect on the human body are noticed: improve well-being and increased athletic performance. When using Eleutherococcus, there was a change in the work of the central nervous system (motor functions): tasks begin to be performed in an organized and accelerated manner without deterioration of well-being, but the volume of strength exercises remained the same. When using the drug leuzea, muscle strength was noted, which allowed to increase the load. There is a positive effect of phytopreparations on the body, namely on the functions of the cardiovascular, central nervous and endocrine systems. In 4 participants who took leuzea, the performance in power competitions improved by 18.5% compared to the control group. The intake of Eleutherococcus and ginseng is accompanied by an increase in the activity of neurotransmitter cells, i.e., the effect on the mesolimbic system. In addition, a study of hematological blood parameters and hormonal statuses at the beginning and end of the study was conducted with the subjects who took leuzea extract. So, the use of the drug leuzea leads to the following positive changes: a more significant increase in ESR, a more significant increase in hemoglobin, compared with the control group. The conclusion is made about the practicality of taking biologically active additives based on some plant adaptogens.

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“…Therefore, the development of fast, precise, and sensitive analytical methods is of great importance for the adequate control of plant products. RCE and PDs are widely used as adaptogens [22,45]. However, the available HPTLC methods for identifying and quantifying PDs, especially for PDs isolated from RCE, are currently quite limited, as evidenced by the data presented in Table 4 [46][47][48][49][50].…”

Section: Discussionmentioning

confidence: 99%

Anti-Adipogenic Activity of Rhaponticum carthamoides and Its Secondary Metabolites

et al. 2023

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Besides their common use as an adaptogen, Rhaponticum carthamoides (Willd.) Iljin. rhizome and its root extract (RCE) are also reported to beneficially affect lipid metabolism. The main characteristic secondary metabolites of RCE are phytoecdysteroids. In order to determine an RCE’s phytoecdysteroid profile, a novel, sensitive, and robust high-performance thin-layer chromatography (HPTLC) method was developed and validated. Moreover, a comparative analysis was conducted to investigate the effects of RCE and its secondary metabolites on adipogenesis and adipolysis. The evaluation of the anti-adipogenic and lipolytic effects was performed using human Simpson–Golabi–Behmel syndrome cells, where lipid staining and measurement of released glycerol and free fatty acids were employed. The HPTLC method confirmed the presence of 20-hydroxyecdysone (20E), ponasterone A (PA), and turkesterone (TU) in RCE. The observed results revealed that RCE, 20E, and TU significantly reduced lipid accumulation in human adipocytes, demonstrating their anti-adipogenic activity. Moreover, RCE and 20E were found to effectively stimulate basal lipolysis. However, no significant effects were observed with PA and TU applications. Based on our findings, RCE and 20E affect both lipogenesis and lipolysis, while TU only restrains adipogenesis. These results are fundamental for further investigations.

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Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of Spinacia oleracea L.

Cited by 7 publications

References 40 publications

Evaluation of the effectiveness of new inulin complexes with extracts from quinoa grains and spinach leaves

Evaluation of the effectiveness of new inulin complexes with extracts from quinoa grains and spinach leaves

The study of the effect of drinks based on extracts of herbal adaptogens on the functional status of athletes during physical activity

Anti-Adipogenic Activity of Rhaponticum carthamoides and Its Secondary Metabolites

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