Add-on mirtazapine to clozapine-responsive early-onset schizophrenia

Moodliar, Seshni; Naguy, Ahmed; Elsori, Dalal

doi:10.1016/j.psychres.2019.112701

Cited by 7 publications

(28 citation statements)

References 5 publications

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“…Four papers did not mention the treatment status of schizophrenia or current/past antipsychotic use 7,9,32,43 . Eighteen papers described previous antipsychotic trials 6,14,17–19,26,30,34–38,40–42,44,48,49 . Of these 18 papers, eight stated the doses of the previous antipsychotics 14,30,34,36,38,40,41,48 and one paper mentioned the duration of the previous antipsychotic trials 41 …”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, patients with schizophrenia may not disclose their LUTS due to embarrassment 15 . LUTS can delay discharge from psychiatric hospitals, 16 cause noncompliance with antipsychotic medications due to the distress they cause to patients 17 and impact the relationship with carers, for instance, if frequent episodes of urinary incontinence occur 18,19 …”

Section: Introductionmentioning

confidence: 99%

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The association of lower urinary tract symptoms with schizophrenia and its treatments: A narrative review

Schofield,

Taylor,

Drake

2023

Neurourology and Urodynamics

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BackgroundA higher incidence of lower urinary tract symptoms (LUTS) in people with schizophrenia compared to the general population is often suggested. However, it is not clear whether this is a genuine association, and whether it is a direct result of schizophrenia itself, or a side‐effect of certain antipsychotics.MethodsWe undertook a narrative review evaluating how the published literature reports the relationship between LUTS and schizophrenia and its treatments. We searched Embase, Ovid Emcare, and Ovid MEDLINE(R) ALL to August 2022, limited to the English language. We selected the following search terms: schizophrenia, schizophrenic, LUTS, overactive bladder, urinary urgency, urinary incontinence, overactive bladder, enuresis, nocturnal enuresis, and voiding dysregulation. We identified seven domains for assessment in advance of commencing the review. These were the categorization, description, and treatment status of schizophrenia; evaluation of LUTS; categorization of LUTS confounders; recapturing of the disease states of both schizophrenia and LUTS after therapies; assessment of the association between LUTS and schizophrenia and/or antipsychotics.ResultsThe association between LUTS and schizophrenia was poorly described. The evidence was low quality and focused predominantly on urinary incontinence as an antipsychotic side effect, neglecting other LUTS. The status of schizophrenia was often incompletely characterized, and no papers made use of a bladder diary or LUTS‐specific questionnaires to assess symptoms. No papers collected information about LUTS in patients not on antipsychotics, nor did any thoroughly evaluate the influence of confounding variables. Despite the tendency of symptoms and severity of both conditions to fluctuate over time, no studies fully assessed the status of both schizophrenia and LUTS at baseline, therapy initiation, and follow‐up.ConclusionsIt is not possible to state whether there is an association between LUTS and schizophrenia or its treatments. This review highlights the need to improve research and clinical management of the urinary tract in schizophrenia, with meticulously designed longitudinal studies.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association of lower urinary tract symptoms with schizophrenia and its treatments: A narrative review

Schofield,

Taylor,

Drake

2023

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…Given this antimuscarinic activity, we have previously reported on mirtazapine use to counterbalance clozapineinduced sialorrhea. 3 As the case continued, trazodone was used successfully in lieu to address the patient's insomnia and anxiety symptoms. But on clinical grounds, this is not always the case.…”

Section: Mirtazapine-associated Prostatismmentioning

confidence: 99%

“…1,2 Because of its structure and pharmacokinetics similarities with chloroquine, HCQ is considered theoretically as nondialyzable. 3 However, objective data concerning HCQ pharmacokinetics in hemodialysis (HD) are lacking. In this setting, we were concerned about the efficacy of HD in clearing HCQ and its impact on HCQ blood therapeutic levels.…”

Section: Measurement Of Hydroxychloroquine Clearance In Intermittent ...mentioning

confidence: 99%