“Add-on” research in clinical trials: Are we asking the right questions?

Glutamine protects against increases in blood ammonia in football players in an exercise intensity-dependent way

“…The serum urate level increased along with ammonia during the exercise, which suggests that the higher ammonia production during the study was probably caused by AMP deamination to maintain the ATP/ADP ratio 6 8 37. In the intermittent protocol, the ammonia level curve for SQL and SAL athletes had a higher base level than that of SQS and SAS.…”

“…Moreover, ammonia can be toxic to both muscles and the central nervous system (CNS), and can induce central and peripheral fatigue 7 – 10. In the worst case scenario, ammonia (300–500 μM) induces severe encephalopathy37 and could lead to coma. Therefore, any strategies to protect against hyperammonemia could enhance physical performance or prevent CNS injuries.…”