Added Value of Fetal MRI in the Evaluation of Fetal Anomalies of the Corpus Callosum: A Retrospective Analysis of 78 Cases

Manevich-Mazor, Mirra; Weissmann-Brenner, Alina; Yosef, Omer Bar; Hoffmann, Chen; Mazor, Roei David; Mosheva, Mariela; Achiron, Reuven; Katorza, E.

doi:10.1055/s-0043-113820

Cited by 10 publications

(8 citation statements)

References 33 publications

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“…8,9 If callosal malformation is suspected an in-utero MRI is recommended. [10][11][12] Malformations of the CC can be characterized by agenesis (ACC), hypoplasia and hyperplasia. 13 The etiology for callosal malformations is usually idiopathic; however, a combination of genetic mechanisms and environmental factors is also described.…”

Section: Introductionmentioning

confidence: 99%

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Neurodevelopmental outcome following prenatal diagnosis of a short corpus callosum

et al. 2019

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Objective Data regarding the neurodevelopmental outcome of fetal short corpus callosum (CC) diagnosed according to standard reference charts is scarce. The purpose of this study was to assess whether the finding is related to neurodevelopmental delay, and to examine reclassification to normal fetal CC length using CC length/EFW ratio. Method Historical prospective cohort study including pregnant women who were referred for fetal neurosonogram due to abnormal CC. Short CC was defined below the 5th percentile according to reference charts. Twenty cases were included in the study group and compared with a control group of 59 normal cases. The patients in the study group were divided into two groups according to CC length/EFW ratio. Children's neurodevelopment was assessed using the Vineland Adaptive Behavior Scale (VABS). Results VABS scores were within normal range in 90% of the cases. There was no significant statistical difference between the study group and the control group. In addition, there was no statistically significant difference between fetuses reclassified as normal callosal length according to CC length/EFW ratio in comparison to the control group. Conclusion The neurodevelopmental outcome of fetuses with diagnosed short CC did not differ from the neurodevelopment of normal fetuses in the control group.

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Section: Introductionmentioning

confidence: 99%

“…Measurement of the fetal CC can be performed by trans‐vaginal or trans‐abdominal sonography . If callosal malformation is suspected an in‐utero MRI is recommended . Malformations of the CC can be characterized by agenesis (ACC), hypoplasia and hyperplasia .…”

Section: Introductionmentioning

confidence: 99%

Neurodevelopmental outcome following prenatal diagnosis of a short corpus callosum

et al. 2019

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“…Not all fetuses had both ultrasound and MRI; however, review of the studies suggested that, when expert neurosonography was performed, fetal MRI rarely changed the nature of the diagnosed CC abnormality, with MRI generally performed to better delineate small remnants of CC tissue and render a diagnosis of partial rather than complete agenesis. In studies in which fetal MRI was performed after conventional screening ultrasound exams, without added expert neurosonography, the reported discrepancy rate between MRI and ultrasound was higher 23,30 .…”

Section: Resultsmentioning

confidence: 99%

Heterogeneity in defining fetal corpus callosal pathology: systematic review

Mahallati

Sotiriadis

Celestin

et al. 2021

Ultrasound in Obstet & Gyne

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Objective Fetal anomalies of the corpus callosum (CC) have been reported in the prenatal imaging literature since 1985, and, especially when isolated, pose challenges for both the patient and fetal medicine specialist. The purpose of this study was to review systematically the literature on prenatally diagnosed abnormalities of the CC, focusing on the terminology used to describe abnormalities other than complete agenesis of the CC, and to assess the heterogeneity of the nomenclature and definitions used. Methods This study was conducted in accordance with the PRISMA statement for reporting systematic reviews. A literature search was performed to identify prospective or retrospective case series or cohort studies, published in English, French, Italian, German or Spanish, reporting fetal imaging findings and describing anomalies of the CC. Quality and risk of bias of the studies were evaluated using the Newcastle–Ottawa scale and a modification of the scale developed by Conde‐Agudelo et al. for other fetal imaging studies. The data extracted included the number of patients, the number of different anomalies identified, the descriptive names of the anomalies, and, where applicable, the definitions of the anomalies, the number of cases of each type of anomaly and the biometric charts used. Secondary tests used to confirm the diagnosis, as well as the postnatal or post‐termination tests used to ascertain the diagnosis, were also recorded. Results The search identified 998 records, and, after review of titles and abstracts and full review of 45 papers, 27 studies were included initially in the review, of which 24 were included in the final analysis. These 24 studies had a broad range of quality and risk of bias and represented 1135 cases of CC anomalies, of which 49% were complete agenesis and the remainder were described using the term partial agenesis or nine other terms, of which five had more than one definition. Conclusions In comparison to the postnatal literature, in the prenatal literature there is much greater heterogeneity in the nomenclature and definition of CC anomalies other than complete agenesis. This heterogeneity and lack of standard definitions in the prenatal literature make it difficult to develop large multicenter pooled cohorts of patients who can be followed in order to develop a better understanding of the genetic associations and neurodevelopmental and psychological outcomes of patients with CC anomalies. As this information is important to improve counseling of these patients, a good first step towards this goal would be to develop a simpler categorization of prenatal CC anomalies that matches better the postnatal literature. © 2020 International Society of Ultrasound in Obstetrics and Gynecology

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“…Agenesis of corpus callosum (ACC) is a rare congenital central nervous system malformation, with the incidence rate of about 0.3-0.7%, and often associated with other fetal malformations [1,2]. ACC can be divided into complete and partial type in morphology, and also Isolated and Compound type with or without other malformations [3,4], different types of ACC have huge difference in prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…ACC can be divided into complete and partial type in morphology, and also Isolated and Compound type with or without other malformations [3,4], different types of ACC have huge difference in prognosis. The precise function of the corpus callosum is not clear yet, which is currently believed to mainly connect the integrated bilateral motor language centers, motor ataxia area and audio/visual area and other areas [4], and often related to pathogenesis of autism, epilepsy, schizophrenia, dementia and other diseases [2]. High-resolution color Doppler ultrasound is the most important means of prenatal screening for ACC, while the rapid development of fetal magnetic resonance imaging (MRI) has provided a new approach for fetal intracranial studies, with high image resolution and free from the influence of factors such as the position of fetus.…”

Section: Introductionmentioning

confidence: 99%

Application of prenatal ultrasonography and magnetic resonance imaging on fetal agenesis of corpus callosum

Min

Li-hua²

2020

Ginekol Pol

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Objectives: To evaluate the diagnostic value and clinical application of prenatal ultrasonography (US) and Magnetic Resonance Imaging (MRI) for different types of fetal Agenesis of the Corpus Callosum (ACC). Material and methods: There were 42 cases of fetal ACC discovered by routine US, including complete ACC 18 cases and partial ACC 24 cases, checked by MRI within 1 week. The results were confirmed by head ultrasound after birth or brain biopsy after labor induction. Results: From prenatal ultrasonic diagnosis, 18 cases were complete ACC and 24 cases were partial ACC. MRI was able to find complete ACC in 11 cases, partial ACC in 16 cases, and non-ACC in 15 cases. Labor induction or birth confirmed that, 11 cases were complete ACC, 14 cases were partial ACC, and 17 cases were non-ACC.The results of different types of ACC were detected by ultrasound and MRI were statistically significant (p < 0.05).MRI examination was superior to ultrasound in specificity, positive predictive value, negative predictive value, Youden index, and diagnostic index. Conclusions: MRI is high specific degrees, diagnostic performance is satisfactory, should be use as a necessary method for prenatal definitive diagnosis of ACC. However, prenatal ultrasound can be tested repeatedly and can be combined with blood flow imaging detection in real time, and it is still the preferred method for screening fetal structural malformation in a comprehensive way, which is suitable for general screening of ACC.

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Added Value of Fetal MRI in the Evaluation of Fetal Anomalies of the Corpus Callosum: A Retrospective Analysis of 78 Cases

Abstract: Fetal MRI effectively detects callosal anomalies and enables satisfactory validation of the presence or absence of callosal anomalies identified by ultrasound and adds valuable data that improves clinical decision making.

Cited by 10 publications

References 33 publications

Neurodevelopmental outcome following prenatal diagnosis of a short corpus callosum

Neurodevelopmental outcome following prenatal diagnosis of a short corpus callosum

Heterogeneity in defining fetal corpus callosal pathology: systematic review

Application of prenatal ultrasonography and magnetic resonance imaging on fetal agenesis of corpus callosum

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