Added value of MRI and high-resolution micro-ultrasound targeting of prostate biopsies for suspicion on cancer

Lopez, L.; Rivière, Jean-Pierre; Pierquet, G.; Piéchaud-Kressmann, J.; Hoepffner, J.; Roche, J-B.; Gaston, R.; Rouffilange, J.; Piéchaud, Thierry

doi:10.1016/s1569-9056(19)34495-1

Cited by 2 publications

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“…At the end of the process, 15 studies were included in the systematic review. 22–34 Of these, 2 were excluded from the meta-analysis, as they did not provide relevant outcomes. 33,34 Overall, 8 trials were published as full texts, 4 as conference abstracts and 3 in 1 prospective multicenter registry study provided by Exact Imaging.…”

Section: Resultsmentioning

confidence: 99%

“…In the analysis of men with GG ≥2 PCa, we included a total of 13 studies comprising 1,125 participants receiving micro-ultrasound–guided, followed by mpMRI-targeted and systematic PB. 22–32 By adding the results of the 3 techniques, 437 patients with GG ≥2 PCa were identified. The micro-ultrasound–guided PB identified 341 and the mpMRI-targeted PB 327 cases (DR 1.05, 95% CI 0.93–1.19, I 2 =0%, fig.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 9 cohort studies with 893 patients undergoing consecutively micro-ultrasound–guided, mpMRI-targeted and systematic PB reported cases of clinically insignificant PCa (GG 1). 22,23,25,26,28–32 The total number of men with clinically insignificant PCa was 158, of which 95 were identified after micro-ultrasound–guided PB and 102 after mpMRI-targeted PB (DR 0.94, 95% CI 0.73–1.22, I 2 =0%, fig. 3).…”

Section: Resultsmentioning

confidence: 99%

“…The same 9 cohort studies reported the total cases of PCa diagnosed through micro-ultrasound–guided, mpMRI-targeted and systematic PB. 22,23,25,26,28–32 From the 503 individuals with positive biopsy, 348 were diagnosed by micro-ultrasound–guided PB and 353 by mpMRI-targeted PB (DR 0.99, 95% CI 0.89–1.11, I 2 =0%, fig. 4).…”

Section: Resultsmentioning

confidence: 99%

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Micro-Ultrasound–Guided vs Multiparametric Magnetic Resonance Imaging-Targeted Biopsy in the Detection of Prostate Cancer: A Systematic Review and Meta-Analysis

et al. 2021

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Purpose: Micro-ultrasound is a novel high resolution ultrasound technology aiming to improve prostate imaging and, consequently, the diagnostic accuracy of ultrasound-guided prostate biopsy. Micro-ultrasoundeguided prostate biopsy may present comparable detection rates to the standard of care multiparametric magnetic resonance imaging-targeted prostate biopsy for the diagnosis of clinically significant prostate cancer. We aimed to compare the detection rate of micro-ultrasound vs multiparametric magnetic resonance imaging-targeted prostate biopsy for prostate cancer diagnosis. Materials and Methods: We performed a systematic review and meta-analysis of diagnostic accuracy studies comparing micro-ultrasoundeguided prostate biopsy to multiparametric magnetic resonance imaging-targeted prostate biopsy as a reference standard test (PROSPERO ID: CRD42020198326). Records were identified by searching in PubMedÒ, ScopusÒ and Cochrane Library databases, as well as in potential sources of gray literature until November 30th, 2020. Results: We included 18 studies in the qualitative and 13 in the quantitative synthesis. In the quantitative synthesis, 1,125 participants received micro-ultrasoundeguided followed by multiparametric magnetic resonance imaging-targeted and systematic prostate biopsy. Micro-ultrasound and multiparametric magnetic resonance imaging-targeted prostate biopsies displayed similar detection rates across all prostate cancer grades. The pooled detection ratio for International Society of Urological Pathology Grade Group !2 prostate cancer was 1.05 (95% CI 0.93e1.19, I 2 [0%), 1.25 (95% CI 0.95e1.64, I 2 [0%) for Grade Group !3 and 0.94 (95% CI 0.73e1.22, I 2 [0%) for clinically insignificant (Grade Group 1) prostate cancer. The overall detection ratio for prostate cancer was 0.99 (95% CI 0.89e1.11, I 2 [0%). Conclusions: Micro-ultrasoundeguided prostate biopsy provides comparable detection rates for prostate cancer diagnosis with the multiparametric magnetic resonance imaging-guided prostate biopsy. Therefore, it could be considered as an attractive alternative to multiparametric magnetic resonance imaging-targeted prostate biopsy. Nevertheless, high quality randomized trials are warranted to corroborate our findings.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations