Addenbrooke's Cognitive Examination-Revised: Effects of Education and Age. Normative Data for the Spanish Speaking Population

Nieto, Antonieta; Galtier, Iván; Hernández, Edith; Velasco, P.E. Bermejo; Barroso, José

doi:10.1093/arclin/acw057

Cited by 11 publications

(8 citation statements)

References 38 publications

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“…This result is consistent with previous studies. 16,24 The optimal cut-off points for identifying MCI from HC, and MNCD from MCI were 71 and 62, respectively, which were found to be lower than the established cut-off values of the original ACE-III 19 and ACE-R. 16 Similarly, in Spanish 20 and Thai, 43 an identical lower cut-off values was reported. There are also studies in other languages, such as Chinese, 44 Cantonese, 45 and Korean, 46 where lower cut-offs were reported.…”

Section: Discussionmentioning

confidence: 78%

“…21 Moreover, ACE-III has also been validated in other conditions, such as brain injury, stroke, and Parkinsonism, 18,22 yielding excellent diagnostic utility and helping clinicians to make more precise decisions about cognitive impairment and dementia. Several studies 24,25 have shown that the cut-off values of ACE-III are influenced by sociodemographic variables, such as age, 26 education, 20 and language. 27 Such factors play an important role when interpreting the suggested cut-off values as they affect the diagnostic accuracy in diverse populations.…”

Section: Introductionmentioning

confidence: 99%

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Hindi Version of Addenbrooke’s Cognitive Examination III: Distinguishing Cognitive Impairment Among Older Indians at the Lower Cut-Offs

Bajpai¹,

Upadhyay²,

Sati³

et al. 2020

CIA

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Background: Screening and diagnostic tests provide an objective measure of cognitive performance and also aid in distinguishing mild cognitive impairment (MCI) from major neurocognitive disorder (MNCD). Further, when such tests are culturally and educationally unbiased, it strengthens their diagnostic utility. This study aimed to validate the Hindi version of Addenbrooke's Cognitive Examination III (ACE-III) in Indian older adults and compare its validity with the Hindi Mini-Mental State Examination (HMSE). Methods: A sample of 412 consenting older adults visiting a memory clinic was recruited into the study. They were categorized into three groups: healthy controls (n=222), MCI (n=70), and MNCD (n=120). The complete clinical protocol was followed. Hindi ACE-III and HMSE were administered and were statistically analyzed. Results: The optimal cutoff values to detect MCI and MNCD with ACE-III were 71 and 62 (AUC: 0.849 and 0.884), respectively, which were slightly higher than with HMSE (AUC: 0.822, 0.861). Education-and age-stratified cutoffs were also computed. Conclusion: Hindi ACE-III has good discriminating power at lower cutoffs than the standard scores in differentiating between MCI and MNCD.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Hindi Version of Addenbrooke’s Cognitive Examination III: Distinguishing Cognitive Impairment Among Older Indians at the Lower Cut-Offs

Bajpai¹,

Upadhyay²,

Sati³

et al. 2020

CIA

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“…Addenbrooke’s Cognitive Examination Revised Test (ACE-R) was performed in each patient before surgery and up to 30 days after. ACE-R is a diagnostic and screening instrument comprised of 5 domains: attention and orientation, memory, verbal fluency, language, and visuo-spatial abilities [ 20 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

Cerebral microemboli in mini-sternotomy compared to mini- thoracotomy for aortic valve replacement: a cross sectional cohort study

Bozhinovska

Jenko

Stupica

et al. 2021

J Cardiothorac Surg

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Background Recently adopted mini-thoracotomy approach for surgical aortic valve replacement has shown benefits such as reduced pain and shorter recovery, compared to more conventional mini-sternotomy access. However, whether limited exposure of the heart and ascending aorta resulting from an incision in the second intercostal space may lead to increased intraoperative cerebral embolization and more prominent postoperative neurologic decline, remains inconclusive. The aim of our study was to assess potential neurological complications after two different minimal invasive surgical techniques for aortic valve replacement by measuring cerebral microembolic signal during surgery and by follow-up cognitive evaluation. Methods Trans-cranial Doppler was used for microembolic signal detection during aortic valve replacement performed via mini-sternotomy and mini-thoracotomy. Patients were evaluated using Addenbrooke’s Cognitive Examination Revised Test before and 30 days after surgical procedure. Results A total of 60 patients were recruited in the study. In 52 patients, transcranial Doppler was feasible. Of those, 25 underwent mini-sternotomy and 27 had mini-thoracotomy. There were no differences between groups with respect to sex, NYHA class distribution, Euroscore II or aortic valve area. Patients in mini-sternotomy group were younger (60.8 ± 14.4 vs.72 ± 5.84, p = 0.003), heavier (85.2 ± 12.4 vs.72.5 ± 12.9, p = 0.002) and had higher body surface area (1.98 ± 0.167 vs. 1.83 ± 0.178, p = 0.006). Surgery duration was longer in mini-sternotomy group compared to mini-thoracotomy (158 ± 24 vs. 134 ± 30 min, p < 0.001, respectively). There were no differences between groups in microembolic load, length of ICU or total hospital stay. Total microembolic signals count was correlated with cardiopulmonary bypass duration (5.64, 95%CI 0.677–10.60, p = 0.027). Addenbrooke’s Cognitive Examination Revised Test score decreased equivalently in both groups (p = 0.630) (MS: 85.2 ± 9.6 vs. 82.9 ± 11.4, p = 0.012; MT: 85.2 ± 9.6 vs. 81.3 ± 8.8, p = 0.001). Conclusion There is no difference in microembolic load between the groups. Total intraoperative microembolic signals count was associated with cardiopulmonary bypass duration. Age, but not micorembolic signals load, was associated with postoperative neurologic decline. Trial registry number clinicaltrials.gov, NCT02697786 14.

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“…Previous studies with the ACE-R have shown that the cutoff points are influenced by sociodemographic variables 35,36. In several studies, with the ACE-III in several studies, the influence of demographic variables has been considered as seen to be an important variable to take into account when interpreting the suggested cutoff points and to improve diagnostic accuracy 9,38,40,44,46…”

Section: Variables To Consider In the Interpretation Of The Cutoff Pomentioning

confidence: 99%

Addenbrooke's cognitive examination III in the diagnosis of dementia: a critical review

Bruno

Vignaga

2019

NDT

109

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Addenbrooke’s cognitive examination III is a screening test that is composed of tests of attention, orientation, memory, language, visual perceptual and visuospatial skills. It is useful in the detection of cognitive impairment, especially in the detection of Alzheimer’s disease and fronto-temporal dementia. The aim of this study is to do a critical review of the Addenbrooke’s cognitive examination III. The different language versions available and research about the different variables that have relationship with the performance of the subject in the ACE-III are listed. The ACE-III is a detection technique that can differentiate patients with and without cognitive impairment, is sensitive to the early stages of dementia, and is available in different languages. However, further research is needed to obtain optimal cutoffs for the different versions and to evaluate the impact of different age, gender, IQ, and education variables on the performance of the test.

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Addenbrooke's Cognitive Examination-Revised: Effects of Education and Age. Normative Data for the Spanish Speaking Population

Abstract: The results show that both age and education have an important effect on ACE-R performance. Consequently, age and education should be taken into account when interpreting results in ACE-R to improve diagnostic accuracy.

Cited by 11 publications

References 38 publications

<p>Hindi Version of Addenbrooke’s Cognitive Examination III: Distinguishing Cognitive Impairment Among Older Indians at the Lower Cut-Offs</p>

<p>Hindi Version of Addenbrooke’s Cognitive Examination III: Distinguishing Cognitive Impairment Among Older Indians at the Lower Cut-Offs</p>

Cerebral microemboli in mini-sternotomy compared to mini- thoracotomy for aortic valve replacement: a cross sectional cohort study

<p>Addenbrooke's cognitive examination III in the diagnosis of dementia: a critical review</p>

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Addenbrooke's Cognitive Examination-Revised: Effects of Education and Age. Normative Data for the Spanish Speaking Population

Abstract: The results show that both age and education have an important effect on ACE-R performance. Consequently, age and education should be taken into account when interpreting results in ACE-R to improve diagnostic accuracy.

Cited by 11 publications

References 38 publications

<p>Hindi Version of Addenbrooke’s Cognitive Examination III: Distinguishing Cognitive Impairment Among Older Indians at the Lower Cut-Offs</p>

<p>Hindi Version of Addenbrooke’s Cognitive Examination III: Distinguishing Cognitive Impairment Among Older Indians at the Lower Cut-Offs</p>

Cerebral microemboli in mini-sternotomy compared to mini- thoracotomy for aortic valve replacement: a cross sectional cohort study

<p>Addenbrooke&#39;s cognitive examination III in the diagnosis of dementia: a critical review</p>

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<p>Addenbrooke's cognitive examination III in the diagnosis of dementia: a critical review</p>