2019
DOI: 10.3389/fpsyt.2019.00311
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Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review

Abstract: Background: Recently, anhedonia has been recognized as an important Research Domain Criterion (RDoC) by the National Institute of Mental Health. Anhedonia is proposed to play an essential role in the pathogenies of both addictive and mood disorders, and possibly their co-occurrence with a single individual. However, up to now, comprehensive information about anhedonia concerning its underlying neurobiological circuitries, the neurocognitive correlates, and their role in addiction, mood disorder, and… Show more

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Cited by 65 publications
(42 citation statements)
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“…Several animal studies show that BDNF deficiency reduces sucrose preference, a loss of sensitivity to reward which has been suggested to model anhedonia (45)(46)(47)(48). Anhedonia is a core symptom of depression, and also plays an essential role in addictive disorders (49,50). In our sample, peripheral BDNF levels were indeed specifically related with self-reported anhedonia levels in the combined sample.…”
Section: Discussionsupporting
confidence: 59%
“…Several animal studies show that BDNF deficiency reduces sucrose preference, a loss of sensitivity to reward which has been suggested to model anhedonia (45)(46)(47)(48). Anhedonia is a core symptom of depression, and also plays an essential role in addictive disorders (49,50). In our sample, peripheral BDNF levels were indeed specifically related with self-reported anhedonia levels in the combined sample.…”
Section: Discussionsupporting
confidence: 59%
“…An alternative-or complementary-hypothesis can be found in the described deficits in the reward system's wanting, i.e., the motivating effect of the anticipatory pleasure before a reward is "consummated". Both substance use and psychotic disorders have been linked to motivational anhedonia, while consummatory pleasure ("liking") appears to be more intact [44,45]. The high frequency of reinforcement in CM might thus help to compensate for the motivational deficits of patients, increasing the chance of behavioral change.…”
Section: Discussionmentioning
confidence: 99%
“…Animal and human studies were the focus in the paper of anhedonia as a transdiagnostic symptom. Anhedonia is a core symptom in depression and it is also involved in addictive disorders [ 74 ]. In this sense, dysregulation of the reward system and alterations in ventral extrapyramidal circuits were described in both disorders [ 75 , 76 ].…”
Section: Discussionmentioning
confidence: 99%