Addiction neurocircuitry and negative affect: A role for neuroticism in understanding amygdala connectivity and alcohol use disorder

Dean, Sarah; Fede, Samantha J.; Diazgranados, Nancy; Momenan, Reza

doi:10.1016/j.neulet.2020.134773

Cited by 13 publications

(10 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, only two studies (Holla et al, 2020; Perini et al, 2020) have examined how RSFC changes during treatment in AUD, and neither of these examined how changes in RSFC relate to changes in alcohol use. Furthermore, while several studies in AUD have examined RSFC between the insula and other cortical (Dai et al, 2021; Dean et al, 2020; Halcomb et al, 2019; Karch et al, 2015; Perini et al, 2020; Vergara et al, 2017) and subcortical areas (Orban et al, 2013), none have examined RSFC of the insula with the BNST.…”

Section: Introductionmentioning

confidence: 99%

Drinking reduction during cognitive behavioral therapy for alcohol use disorder is associated with a reduction in anterior insula‐bed nucleus of the stria terminalis resting‐state functional connectivity

Srivastava

Sanchez-Peña

Levin

et al. 2021

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Background Connectivity between the anterior insula (AI) and the bed nucleus of the stria terminalis (BNST) may play a role in negative emotions that drive compulsive drinking in patients with alcohol use disorder (AUD). We hypothesized that reductions in drinking during cognitive behavioral therapy (CBT), an effective treatment that teaches regulation (coping) skills for managing negative emotions during abstinence, would be associated with reductions in resting‐state functional connectivity (RSFC) between the AI and the BNST. Methods We included 18 patients with a Diagnostic and Statistical Manual of Mental Disorders, fifth edition diagnosis of AUD who were (1) seeking treatment and (2) drinking heavily at baseline. We measured RSFC as Pearson's correlation between the BNST and multiple regions of interest in the insula at baseline and after completion of 12 weeks of a single‐arm clinical trial of outpatient CBT. We also assessed the number of heavy drinking days over the previous 28 days (NHDD) at both time points. We used 1‐sample t‐tests to evaluate AI‐BNST RSFC at baseline, paired t‐tests to evaluate changes in AI‐BNST RSFC from pre‐CBT to post‐CBT, and linear regression to evaluate the relationship between changes in AI‐BNST RSFC and NHDD. Results We found a significant positive RSFC between the AI and the BNST at baseline (p = 0.0015). While there were no significant changes in AI‐BNST RSFC from pre‐ to post‐CBT at the group level (p = 0.42), we found that individual differences in reductions in AI‐BNST RSFC from pre‐ to post‐CBT were directly related to reductions in NHDD from pre‐ to post‐CBT (r = 0.73, p = 0.0008). Conclusions These findings provide preliminary evidence that reduced AI‐BNST RSFC may be a mechanism of drinking reduction in AUD and that AI‐BNST RSFC may be a target for CBT and possibly other treatments.

show abstract

Section: Introductionmentioning

confidence: 99%

Drinking reduction during cognitive behavioral therapy for alcohol use disorder is associated with a reduction in anterior insula‐bed nucleus of the stria terminalis resting‐state functional connectivity

Srivastava

Sanchez-Peña

Levin

et al. 2021

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

show abstract

“…It is also connected to the orbitofrontal cortex, which may be the mechanism by which withdrawal/negative affects influence the preoccupation/anticipation stage. 9 That said, the preoccupation/anticipation stage, characterized by craving and executive function deficits, involves prefrontal activation mediated by glutamate. 9,10 Beyond that, human imaging studies have reported that deficits in executive function could be associated with decreases in frontal cortex activity, which interfere with decision-mak-ing, self-regulation, inhibitory control, and working memory, and might involve disrupted GABAergic activity in the prefrontal cortex.…”

Section: Neurocircuitrymentioning

confidence: 99%

“…9 The binge/intoxication portion of the cycle is characterized by the rewarding effects and drug-seeking behavior of any drug addiction. 9 Positron emission tomography (PET) studies have shown that intoxicating doses of alcohol and drugs release dopamine and opioid peptides in the ventral striatum. Beyond that, γ-aminobutyric acid (GABA), glutamate, serotonin, acetylcholine, and endocannabinoid systems, which act at the level of either the VTA or of the NAcc, are related to this stage.…”

Section: Neurocircuitrymentioning

confidence: 99%

Neurosurgery in the Treatment of Alcohol Use Disorder: A Systematic Literature Review

Almeida

Silva

2022

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

View full text Add to dashboard Cite

Alcohol abuse has impacts on public health worldwide. Conservative treatment to achieve abstinence consists of detoxification combined with psychotherapy and the use of drugs, but it is estimated that only half of the individuals achieve long-term abstinence with the available treatments. In this sense, neurosurgery appears as a therapeutic proposal. The present study aimed to gather information about the circuitry related to alcohol use disorder (AUD), to describe possible surgical targets, and to establish whether a surgical approach could be a safe and effective treatment option. A systematic review of the literature was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. The 14 selected articles analyze ablative operations, deep brain stimulation (DBS), and a new procedure in which the patient is first submitted to repetitive transcranial magnetic stimulation to evaluate their response, and later an implant is surgically positioned on the evaluated target to obtain more lasting results. The most relevant outcomes were found when the anterior cingulate cortex (ACC) and the nucleus accumbens (NAcc) were used as targets, demonstrating a large reduction in alcohol intake and even its cessation. However, important side effects were observed, such as psychotic symptoms, right frontal venous infarction, seizures after implantation in the ACC and a hypomanic period after DBS in the NAcc, which could be reversed. Due to the lack of studies involving the surgical treatment of AUD, more clinical trials are needed to compare targets, to assess surgical techniques, and to estimate the safety of these techniques.

show abstract

“…Studies on humans showed that the rise of DA level in the dorsal striatum was significantly correlated with the increase of craving for cocaine, [83,84]. Likewise, pharmacological blockade of the dorsolateral striatum after forced abstinence resulted in the reduction of drug-seeking behavior in rats [85][86][87].…”

Section: A Diagram Depicting the Spiralling Distress -Addiction Cycle From Social Psychological And Neurobiological Viewpoints Nb Stage 1mentioning

confidence: 99%

“…Administration of antagonists for neurotransmitters significantly reduced substance intake in response to withdrawal and stress. Similarly stopping the activation of stress receptors in the brain lowered alcohol consumption in both alcohol-dependent rats and humans with alcohol use disorder [86,87]. Hence, the desire to remove the negative feelings associated with withdrawal can be a strong driving force to continuous consumption of the substance since the taking of the substance at least momentarily relieves the negative feelings caused by the withdrawal.…”

Section: Stage 2: Withdrawal/negative Affectmentioning

confidence: 99%

Psychopharmacological Perspectives and Diagnosis of Substance Use Disorder

Duresso¹

2021

Addictions - Diagnosis and Treatment

View full text Add to dashboard Cite

A considerable body of research has accumulated over several decades and altered the current understanding of substance use and its effects on the brain. This knowledge has improved the perception of the disease of addiction and has opened the door to new ways of thinking about diagnosis, prevention, and treatment of substance use disorders. The purpose of the current chapter is to briefly outline and summarize the major psychopharmacological framework underlying substance use disorder (SUD) and the factors that involve in the transformation of some people from recreational use or misuse of alcohol or drugs to SUD. The chapter explains the overall neurocircuitry theories of the addiction cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. It briefly discusses how psychoactive substances produce changes in brain functioning that facilitate the development of addiction and contribute to craving which eventually leads to relapse. The chapter also deals with similarities and differences among various classes of addictive substances in their effects on the brain and behavior and briefly describes the main risk factors that involve SUD. Finally, an attempt is made to briefly discuss the major DSM 5 based behavioral criteria that involve SUD, corresponding to the most abused substances worldwide.

show abstract

Addiction neurocircuitry and negative affect: A role for neuroticism in understanding amygdala connectivity and alcohol use disorder

Cited by 13 publications

References 25 publications

Drinking reduction during cognitive behavioral therapy for alcohol use disorder is associated with a reduction in anterior insula‐bed nucleus of the stria terminalis resting‐state functional connectivity

Drinking reduction during cognitive behavioral therapy for alcohol use disorder is associated with a reduction in anterior insula‐bed nucleus of the stria terminalis resting‐state functional connectivity

Neurosurgery in the Treatment of Alcohol Use Disorder: A Systematic Literature Review

Psychopharmacological Perspectives and Diagnosis of Substance Use Disorder

Contact Info

Product

Resources

About