1994
DOI: 10.1249/00005768-199408000-00003
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Adding ??-2 agonism does not improve ??-1 blockade exercise responses in hypertensives

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Cited by 4 publications
(3 citation statements)
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“…However, according to our findings these did not appear to affect V o 2 (ml/kg/min), as there were no significant differences in this factor in the post-MI subjects taking and not taking β-blockers. Similarly, other studies have observed β-blocking medication not to affect submaximal V o 2 levels,22 25 although β-blockers have been shown to affect V o 2 max 25. Furthermore, 90% of the post-MI subjects were taking a statin, and although our findings suggest that these did not affect V o 2 (ml/kg/min), they can cause a degree of myopathy 26.…”
Section: Discussionsupporting
confidence: 58%
“…However, according to our findings these did not appear to affect V o 2 (ml/kg/min), as there were no significant differences in this factor in the post-MI subjects taking and not taking β-blockers. Similarly, other studies have observed β-blocking medication not to affect submaximal V o 2 levels,22 25 although β-blockers have been shown to affect V o 2 max 25. Furthermore, 90% of the post-MI subjects were taking a statin, and although our findings suggest that these did not affect V o 2 (ml/kg/min), they can cause a degree of myopathy 26.…”
Section: Discussionsupporting
confidence: 58%
“…Secondly, and as we found, neither atenolol nor metoprolol therapy have been reported to affect CVR in several other studies. 5,6,8,12 In this context however, there remains the possibility that the effect of β 1 -adrenergic blocking agents on CVR may reflect a balance between emerging unopposed α-adrenergic vasoconstrictive effects and β 2 -adrenergic vasodilating effects. Nevertheless, the present investigations have shown that the absence of demonstrable effect of atenolol therapy on CVR was accompanied by the absence of its effect on the simultaneously measured peripheral vasoconstrictive sympathetic drive.…”
Section: Discussionmentioning
confidence: 99%
“…β-Blockade can result in certain adverse responses, such as bronchoconstriction, generalized fatigue, reduction in heart rate, reduction in cardiac output, possible reduction in skeletal muscle blood flow and reduction in exercise capacity [20]. Although β-blockade is generally found not to alter ventilation during rest or exercise, these other adverse responses would make β-blockade an unacceptable tool for examination of ventilatory or metabolic responses to exercise.…”
Section: Discussionmentioning
confidence: 99%