Adding glucose to food and solutions to enhance fructose absorption is not effective in preventing fructose‐induced functional gastrointestinal symptoms: randomised controlled trials in patients with fructose malabsorption

Tuck, Caroline J; Ross, Linda; Barrett, Jacqueline Susanne; Muir, Jane G.

doi:10.1111/jhn.12409

Cited by 23 publications

(22 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…107 Enzyme supplementation therapy may also be a therapeutic target for sucrose-isomaltase deficiency, although few studies exist. 108 The importance of studying the effect of such targeted therapies in the correct population group was highlighted when additional glucose was unable to improve gastrointestinal tolerance to excess fructose in FBD patients despite reduced gas production 109 and physiological mechanisms suggesting it would. 110 The second way to improve tolerance is more relevant to a longer term scenario.…”

Section: Duration Of Therapymentioning

confidence: 99%

Dietary therapies for functional bowel symptoms: Recent advances, challenges, and future directions

Tuck

Vanner

2017

Neurogastroenterology Motil

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Duration Of Therapymentioning

confidence: 99%

Dietary therapies for functional bowel symptoms: Recent advances, challenges, and future directions

Tuck

Vanner

2017

Neurogastroenterology Motil

Self Cite

View full text Add to dashboard Cite

show abstract

“…27 Second, it is still unproven that the same dose of fructose administered in real food (see Table 6 for fructose contents of commonly ingested foods) actually causes symptoms compared to 35 g fructose administered in water in the fasted state during a fructose-hydrogen breath test. 27 Second, it is still unproven that the same dose of fructose administered in real food (see Table 6 for fructose contents of commonly ingested foods) actually causes symptoms compared to 35 g fructose administered in water in the fasted state during a fructose-hydrogen breath test.…”

Section: Implications For Clinical Managementmentioning

confidence: 99%

Review article: biological mechanisms for symptom causation by individual FODMAP subgroups ‐ the case for a more personalised approach to dietary restriction

Wang

Camilleri

Vanner

et al. 2019

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Background: Due to the paucity of targeted therapy for irritable bowel syndrome (IBS), many patients turn to dietary modifications for symptom management. The combination of five subgroups of poorly absorbed and rapidly fermented carbohydrates-fructans, galacto-oligosaccharides, lactose, excess fructose and polyolsare thought to trigger gastrointestinal symptoms and are referred to collectively as "FODMAPs". Aims:To examine the biological plausibility and mechanisms by which foods high in specific FODMAP subgroups cause symptoms, and to use this information to explore the possibility of targeting select dietary components to allow for a more personalised approach to dietary adjustment Methods: Recent literature was analysed via search databases including Medline, PubMed and Scopus.Results: Lactose, fructans and galacto-oligosaccharides have strong biologic plausibility for symptom generation due to lack of hydrolases resulting in distention from osmosis and rapid fermentation. However, excess fructose and polyols may only cause symptoms in specific individuals when consumed in high doses, but this remains to be established. There is evidence to suggest that certain patient characteristics such as ethnicity may predict response to lactose, but differentiation of other subgroups is difficult prior to dietary manipulation. Conclusions:While some clear mechanisms of action for symptom generation have been established, further research is needed to understand which patients will respond to specific FODMAP subgroup restriction. We suggest that clinicians consider in some patients a tailored, personalised "bottom-up" approach to the low-FODMAP diet, such as dietary restriction relevant to the patients' ethnicity, symptom profile and usual dietary intake.

show abstract

“…Of the FODMAP subgroups, the actions of excess fructose have been particularly challenging to elucidate, especially given their complex interaction with glucose co‐transport. Unfortunately, combining glucose with either excess fructose or fructans does not mitigate their effects on symptoms . Tests that identify susceptible patients that malabsorb FODMAPs, and in particular excess fructose, have remained elusive.…”

mentioning

confidence: 99%

Fermentable carbohydrates in functional bowel disorders: New insights

Vanner

Whelan

2019

Neurogastroenterology Motil

View full text Add to dashboard Cite

Adding glucose to food and solutions to enhance fructose absorption is not effective in preventing fructose‐induced functional gastrointestinal symptoms: randomised controlled trials in patients with fructose malabsorption

Abstract: The absence of a favourable response on symptoms does not support the concomitant intake of glucose with foods high in either fructose or fructans in patients with functional bowel disorders.

Cited by 23 publications

References 35 publications

Dietary therapies for functional bowel symptoms: Recent advances, challenges, and future directions

Dietary therapies for functional bowel symptoms: Recent advances, challenges, and future directions

Review article: biological mechanisms for symptom causation by individual FODMAP subgroups ‐ the case for a more personalised approach to dietary restriction

Fermentable carbohydrates in functional bowel disorders: New insights

Contact Info

Product

Resources

About