Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial

Mijwel, Sara; Backman, Malin; Bolam, Kate A.; Jervaeus, Anna; Sundberg, Carl Johan; Margolin, Sara; Browall, Maria; Rundqvist, Helene; Wengström, Yvonne

doi:10.1007/s10549-017-4571-3

Cited by 142 publications

(254 citation statements)

References 52 publications

Supporting

Mentioning

230

Contrasting

Unclassified

Order By: Relevance

“…A recent review of Powers et al (2019), including preclinical studies, suggests that endurance exercise training performed prior to doxorubicin treatment protects against doxorubicin‐induced skeletal muscle atrophy by the prevention of excess oxidative stress and the activation of proteolytic signalling pathways . Indeed, the beneficial effects of exercise are confirmed in human studies with several clinical trials showing that combined resistance and endurance training has positive effects on muscle strength in cancer patients undergoing chemotherapy . Mijwel et al (2018) compared the effects of different exercise regimens (moderate‐intensity aerobic combined with high‐intensity interval training vs resistance combined with high‐intensity interval training) with usual care on skeletal muscle morphology in breast cancer patients receiving chemotherapy and found that resistance combined with high‐intensity interval training resulted in a significant increase in type I muscle fibres, whereas aerobic combined with high‐intensity training counteracted a decline in type I muscle fibres .…”

Section: Discussionmentioning

confidence: 99%

Doxorubicin‐induced skeletal muscle atrophy: Elucidating the underlying molecular pathways

et al. 2019

Self Cite

View full text Add to dashboard Cite

Aim Loss of skeletal muscle mass is a common clinical finding in cancer patients. The purpose of this meta‐analysis and systematic review was to quantify the effect of doxorubicin on skeletal muscle and report on the proposed molecular pathways possibly leading to doxorubicin‐induced muscle atrophy in both human and animal models. Methods A systematic search of the literature was conducted in PubMed, EMBASE, Web of Science and CENTRAL databases. The internal validity of included studies was assessed using SYRCLE’s risk of bias tool. Results Twenty eligible articles were identified. No human studies were identified as being eligible for inclusion. Doxorubicin significantly reduced skeletal muscle weight (ie EDL, TA, gastrocnemius and soleus) by 14% (95% CI: 9.9; 19.3) and muscle fibre cross‐sectional area by 17% (95% CI: 9.0; 26.0) when compared to vehicle controls. Parallel to negative changes in muscle mass, muscle strength was even more decreased in response to doxorubicin administration. This review suggests that mitochondrial dysfunction plays a central role in doxorubicin‐induced skeletal muscle atrophy. The increased production of ROS plays a key role within this process. Furthermore, doxorubicin activated all major proteolytic systems (ie calpains, the ubiquitin‐proteasome pathway and autophagy) in the skeletal muscle. Although each of these proteolytic pathways contributes to doxorubicin‐induced muscle atrophy, the activation of the ubiquitin‐proteasome pathway is hypothesized to play a key role. Finally, a limited number of studies found that doxorubicin decreases protein synthesis by a disruption in the insulin signalling pathway. Conclusion The results of the meta‐analysis show that doxorubicin induces skeletal muscle atrophy in preclinical models. This effect may be explained by various interacting molecular pathways. Results from preclinical studies provide a robust setting to investigate a possible dose‐response, separate the effects of doxorubicin from tumour‐induced atrophy and to examine underlying molecular pathways. More research is needed to confirm the proposed signalling pathways in humans, paving the way for potential therapeutic approaches.

show abstract

Section: Discussionmentioning

confidence: 99%

Doxorubicin‐induced skeletal muscle atrophy: Elucidating the underlying molecular pathways

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…b Participants who did not drop out before baseline (n = 210) UC overall n = 60, weak-normal SOC n = 42, strong SOC n = 18. b Total effects of the exercise interventions on fatigue, symptoms, and health-related quality of life have been previously reported [12] population, the distribution includes a larger proportion of people with strong SOC (33% vs. 39% individuals with strong SOC, respectively) [30]. It has been shown that SOC is positively associated with perceived health [11].…”

Section: Sense Of Coherencementioning

confidence: 95%

“…In total, 240 women signed informed consent and 182 (76%) participants completed both baseline and follow-up testing (Appendix 1) [12]. Two hundred and forty women with breast cancer undergoing chemotherapy were randomly allocated to either AT-HIIT (n = 80), RT-HIIT (n = 79), or UC (n = 81).…”

Section: Participantsmentioning

confidence: 99%

“…In the randomized controlled 'Optimal Training for Women with Breast Cancer' (OptiTrain) study, we demonstrated that combined resistance and aerobic high-intensity interval training during chemotherapy had a significant beneficial effect on cancer-related fatigue [12]. The main objective of the present study was to examine the SOC of patients participating in the OptiTrain trial and to assess how patient characteristics are associated with SOC.…”

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Sense of coherence and its relationship to participation, cancer-related fatigue, symptom burden, and quality of life in women with breast cancer participating in the OptiTrain exercise trial

Hiensch

Bolam

Mijwel

et al. 2020

Support Care Cancer

Self Cite

View full text Add to dashboard Cite

Purpose This study examined the Sense of Coherence (SOC) of patients participating in the randomized controlled 'Optimal Training for Women with Breast Cancer' (OptiTrain) study and assessed how patient characteristics were associated with SOC. Secondary aims were to assess the association between SOC and patients' participation in this study and to determine whether SOC moderates the effect of the 16-week exercise intervention on fatigue, quality of life (QoL), and symptom burden in women with breast cancer undergoing chemotherapy. Methods Modified Poisson regression analyses were conducted to determine the relative risk of weak-normal SOC versus strong SOC in terms of exercise session attendance, study and intervention dropout, and long absence rates. Analyses of covariance were performed to assess whether SOC moderated the effect of the exercise intervention (p interaction ≤ 0.10). Results Two hundred and forty women with early breast cancer (mean age 53 ± 10) participated in the OptiTrain study. Women with strong SOC reported less fatigue, lower symptom burden, and higher QoL. Women with weak-normal SOC were significantly more likely to drop out from the OptiTrain study and tended to have slightly poorer exercise session attendance. Women with breast cancer and weaker SOC benefitted as much from the exercise intervention, in terms of fatigue and QoL, as those with stronger SOC (p interaction > 0.10). Conclusions Strong SOC appears to be associated with a more positive subjective state of health. Women with weak-normal SOC may need additional support to encourage participation and adherence in exercise trials. Assessing SOC may assist clinicians to identify and provide extra support for participants with weak SOC, who may be less inclined to participate in exercise programs.

show abstract

“…Cancer-related fatigue was selfassessed at baseline and at 16 wk using the EORTC QLQ-C30 questionnaire (version 3.0) (31). Muscle strength and EORTC-QLQ-C30 questionnaire results including all patients of the OptiTrain trial have been published previously (32). Higher scores on the EORTC-QLQ-C30 scale indicate higher levels of fatigue.…”

Section: Other Measuresmentioning

confidence: 99%

Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer

et al. 2018

Self Cite

View full text Add to dashboard Cite

Exercise has been suggested to ameliorate the detrimental effects of chemotherapy on skeletal muscle. The aim of this study was to compare the effects of different exercise regimens with usual care on skeletal muscle morphology and mitochondrial markers in patients being treated with chemotherapy for breast cancer. Specifically, we compared moderate-intensity aerobic training combined with high-intensity interval training (AT-HIIT) and resistance training combined with high-intensity interval training (RT-HIIT) with usual care (UC). Resting skeletal muscle biopsies were obtained pre- and postintervention from 23 randomly selected women from the OptiTrain breast cancer trial who underwent RT-HIIT, AT-HIIT, or UC for 16 wk. Over the intervention, citrate synthase activity, muscle fiber cross-sectional area, capillaries per fiber, and myosin heavy chain isoform type I were reduced in UC, whereas RT-HIIT and AT-HIIT were able to counteract these declines. AT-HIIT promoted up-regulation of the electron transport chain protein levels vs. UC. RT-HIIT favored satellite cell count vs. UC and AT-HIIT. There was a significant association between change in citrate synthase activity and self-reported fatigue. AT-HIIT and RT-HIIT maintained or improved markers of skeletal muscle function compared with the declines found in the UC group, indicating a sustained trainability in addition to the preservation of skeletal muscle structural and metabolic characteristics during chemotherapy. These findings highlight the importance of supervised exercise programs for patients with breast cancer during chemotherapy.-Mijwel, S., Cardinale, D. A., Norrbom, J., Chapman, M., Ivarsson, N., Wengström, Y., Sundberg, C. J., Rundqvist, H. Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer.

show abstract

Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial

Cited by 142 publications

References 52 publications

Doxorubicin‐induced skeletal muscle atrophy: Elucidating the underlying molecular pathways

Doxorubicin‐induced skeletal muscle atrophy: Elucidating the underlying molecular pathways

Sense of coherence and its relationship to participation, cancer-related fatigue, symptom burden, and quality of life in women with breast cancer participating in the OptiTrain exercise trial

Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer

Contact Info

Product

Resources

About