Addition of Daptomycin to Levofloxacin Increased the Efficacy of Levofloxacin Monotherapy against a Methicillin-SusceptibleStaphylococcus aureusStrain in Experimental Meningitis and Prevented Development of Resistance
Abstract:Daptomycin and levofloxacin were tested as monotherapies and in combination against the antibiotic-susceptible S. aureus strain MSSA 1112 in a rabbit meningitis model and the effect of the combination on induction of resistance was determined in vitro. Changes of the susceptibility to fluoroquinolones and daptomycin was determined by the measurement of the MIC and mutations were detected by whole genome sequence comparison of the mutants with the parent strain MSSA 1112. Meningitis was induced by intracisterna… Show more
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