Addition of dexmedetomidine to ropivacaine in subcostal transversus abdominis plane block potentiates postoperative analgesia among laparoscopic cholecystectomy patients: A prospective randomized controlled trial

B, Sarvesh; Shivaramu, B T; Sharma, Kanchan; Agarwal, Amit

doi:10.4103/aer.aer_141_18

Cited by 11 publications

(3 citation statements)

References 22 publications

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“…The results showed that dexmedetomidine when added to ropivacaine, increased the post-operative analgesia duration while significantly decreasing the need for opioids without increasing the risk of severe adverse effects. 8 A similar study was performed by Kaygusuz et al, on sensory and motor block duration, time before initial analgesic usage, and the overall demand for analgesics, which were shown to be substantially longer in Group D (5% levobupivacaine 39 mL+1 mL dexmedetomidine). In addition, individuals in Group D had lower VAS values at 5, 10, and 12 h postoperatively compared to patients in Group L (39 mL levobupivacaine).…”

Section: Discussionmentioning

confidence: 57%

A comparative study of 0.25% levobupivacaine and 0.25% levobupivacaine with dexmedetomidine in ultrasound-guided transverse abdominis plane block for post-operative analgesia in infraumbilical surgeries

Dhanashree PJ,

Bammidi Muralikrishna,

Venkata Krishna Gollapalli

et al. 2023

Asian J Med Sci

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Background: Transversus abdominis plane (TAP) block delivers excellent analgesia with few side effects. Previous research suggests that the efficacy and duration of the block can be increased by adding adjuvants such as dexmedetomidine to the local anesthetics. Aims and Objectives: To compare the post-operative analgesic effectiveness of 0.25% levobupivacaine and 0.25% levobupivacaine with dexmedetomidine 1 μg/kg in US-guided TAP block in infraumbilical surgery patients. Materials and Methods: Ultrasound-guided TAP block was given to sixty patients. Patients consented for infraumbilical surgery, and patients were randomly assigned to two groups: Group L received 20 mL of 0.25% levobupivacaine alone and Group LD received 20 mL of 0.25% levobupivacaine with dexmedetomidine 1 μg/kg. The efficacy of analgesia was measured in terms of degree and duration of analgesia; the post-operative pain was evaluated using a visual analog scale (VAS). The Chi-square test and Student’s t-test were used for statistical analysis. Results: Result shows that there is no statistically significant difference in gender, age group, weight, height, BMI, and type of surgery between groups, with a P=0.40, 0.83, 0.37, 0.59, and 0.93, respectively. In addition, there is no statistically significant difference in the duration of surgery between the groups (P=0.63). However, it was observed statistically significant differences in the onset of analgesia requirement, duration of effect of analgesia, and the total anesthesia consumption between the experimental groups with a P=0.001, 0.001, and 0.001, respectively. No significant difference in VAS was observed initially but was significant in later hours. Conclusion: Adding dexmedetomidine to 0.25% levobupivacaine enhanced the efficacy of the block and duration of post-operative analgesia compared to 0.25% levobupivacaine alone.

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Section: Discussionmentioning

confidence: 57%

A comparative study of 0.25% levobupivacaine and 0.25% levobupivacaine with dexmedetomidine in ultrasound-guided transverse abdominis plane block for post-operative analgesia in infraumbilical surgeries

Dhanashree PJ,

Bammidi Muralikrishna,

Venkata Krishna Gollapalli

et al. 2023

Asian J Med Sci

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“…Bergmans et al [ 44 ] performed an evaluation of pain relief after TAP block procedure and concluded that it is part of a multimodal approach to pain management in children undergoing abdominal surgery, which is consistent with our findings. To support this fact, the ASA recommended that multimodal approaches should include round-the-clock treatment with acetaminophen, nonselective or selective COX-2 inhibitory NSAID, and regional blockade with local anesthetics [ 45 ]. However, it is necessary to control the inflammatory factors in the periphery because the surgical intervention itself causes an increase in inflammation, which is the cause of the intervention.…”

Section: Resultsmentioning

confidence: 99%

Postoperative Pain Management in Children Undergoing Laparoscopic Appendectomy: A Scoping Review

et al. 2023

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Laparoscopic appendectomy (LA) is one of the most commonly performed surgical procedures in children and is associated with extreme postoperative discomfort due to peritoneal inflammation and infection. The main objective of this study was to investigate the effects of postoperative pain (POP) in children after laparoscopic appendectomy. Articles describing or evaluating the control of POP in children with LA were considered eligible. All available literature such as randomized controls, prospective controls, retrospective as well as clinical studies were considered. A comprehensive search was performed in PubMed, Medline, Embase, Cochrane Library, Clinical trials.gov, and Google scholar. The initial search took place on 23 April 2021, and was updated on 24 August 2021. There were no language or date restrictions. Each of the included articles was evaluated separately by two independent reviewers. Additional papers were found by searching the reference lists of eligible studies. Eighteen papers were considered. All papers, and many of them used different methods to treat POP in children undergoing LA, such as lidocaine infusion, different analgesic approaches, ultrasound-guided transverse abdominis blockade (UGTAP), ultrasound-guided quadratus lumborum blockade (UGQLB), and comparison of open appendectomy (OA) with local anesthetics in relation to POP management in children. Laparoscopic appendectomy is the surgical procedure preferred by clinicians compared with open appendectomy in children. A multimodal analgesic approach is optimal and efficient surgical techniques such as UGBRSB, UGQLB, and UGTAP block might significantly impact POP in children except that there are contraindications. Dexmedetomidine proved to be an effective adjuvant that can enhance the effect of local anesthetics. The lack of a sufficient number of studies may be a factor affecting our confidence in the results of this study. Therefore, further evidence-based randomized control trials with a large sample size are needed to provide clarity.

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“…Adding Dexmedetomidine to Bupivacaine in ESP has a highly effective sedative and analgesic effect [14] . It has been found that, in many experimental and clinical regional block practices, the addition of dexmedetomidine (0.5µg/kg) to the local anesthetic reduces tissue and nerve damage, increases duration of sensory and motor block, and reduces postoperative pain.…”

Section: Introductionmentioning

confidence: 99%

Dexmedetomidine Added to Bupivacaine Versus Bupivacaine Alone in Ultrasound-Guided Erector Spinae Block in Spine Surgeries for Post Operative Pain Management: A Randomized Controlled Study

MANAR M. ELKHOLY, M.D.*; AHMED

2023

The Medical Journal of Cairo University

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Background: During spine surgery, mechanical and thermal trauma can cause muscle ischemia and damage to nerves innervating the paraspinal muscles. Therefore, it is often characterized by severe and diffuse pain in the postoperative period, so adequate postoperative analgesia is essential to allow early mobilization, reducing the incidence of postoperative respiratory complications, and decrease the risk of chronic pain syndrome. Aim of Study:To investigate the effectiveness of a mixture of dexmedetomidine and bupivacaine versus bupivacaine alone for ESB for postoperative analgesia in spine surgery.

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Addition of dexmedetomidine to ropivacaine in subcostal transversus abdominis plane block potentiates postoperative analgesia among laparoscopic cholecystectomy patients: A prospective randomized controlled trial

Cited by 11 publications

References 22 publications

A comparative study of 0.25% levobupivacaine and 0.25% levobupivacaine with dexmedetomidine in ultrasound-guided transverse abdominis plane block for post-operative analgesia in infraumbilical surgeries

A comparative study of 0.25% levobupivacaine and 0.25% levobupivacaine with dexmedetomidine in ultrasound-guided transverse abdominis plane block for post-operative analgesia in infraumbilical surgeries

Postoperative Pain Management in Children Undergoing Laparoscopic Appendectomy: A Scoping Review

Dexmedetomidine Added to Bupivacaine Versus Bupivacaine Alone in Ultrasound-Guided Erector Spinae Block in Spine Surgeries for Post Operative Pain Management: A Randomized Controlled Study

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