Addition of meperidine to bupivacaine for spinal anaesthesia for Caesarean section†

Yu, S. C.; Kee, Warwick D. Ngan; Kwan, Alan

doi:10.1093/bja/88.3.379

Cited by 71 publications

(54 citation statements)

References 22 publications

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“…Patients who had 5 µg of sufentanil had significantly longer duration of analgesia than those who had 10µg fentanyl. Yu et al in their study [14] showed that there was a significant difference in the effective duration of analgesia (defined as the time of intrathecal injection to the first patient controlled analgesia demand), following addition of 10mg pethidine to 2.0 ml of 0.5% hyperbaric bupivacaine (mean 234 minutes) compared with the addition of saline (mean 125 minutes) which was also the same in our study.…”

Section: Discussionsupporting

confidence: 85%

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Analgesic Effects of Intrathecally Administered Fentanyl in Spinal Anaesthesia for Lower Limb Surgery

et al. 2013

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Section: Discussionsupporting

confidence: 85%

“…Neuraxial administration of other opioids such as sufentanil and meperidine with local anaesthetics (LAs) has also been demonstrated to prolong early postoperative analgesia compared with the use of local anaesthetic agents alone [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Analgesic Effects of Intrathecally Administered Fentanyl in Spinal Anaesthesia for Lower Limb Surgery

et al. 2013

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“…In another similar study, Yu et al [11] found that the group receiving added meperidine had a greater incidence of intraoperative nausea or vomiting than did the group receiving added saline. Farzi et al [12] found no statistically significant difference in the occurrence of nausea and vomiting, and concluded that their occurrence during the operation may be partly due to surgical manipulation and peritoneal stimulation.…”

Section: Discussionmentioning

confidence: 91%

Beneficial effects of the addition of intrathecal fentanyl to bupivacaine for spinal anesthesia in cesarean section

2017

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Background: The addition of fentanyl or epinephrine to bupivacaine enhances the quality of intraoperative spinal anesthesia during cesarean section. This study aimed to evaluate the beneficial effects of adding fentanyl or epinephrine to bupivacaine in spinal anesthesia solutions used for patients undergoing cesarean section. Methods: This retrospective study included 391 patients who underwent cesarean section under spinal anesthesia between March 2009 and February 2014. Parturients were categorized into group N (no addition; n = 103), group E (addition of epinephrine; n = 196), and group F (addition of fentanyl; n = 92). Perioperative hemodynamic changes, complications, sensory recovery times, Apgar scores, and cord blood pH were analyzed. Results: Nausea and vomiting occurred more frequently in group E than in the other two groups (P ＜ 0.001 and P = 0.027, respectively). The mean sensory recovery times to T10 level showed statistically significant intergroup differences (P ＜ 0.001). Group F showed the highest 1-min and 5-min Apgar scores, with statistically significant differences amongst the three groups (P = 0.007 and P ＜ 0.001, respectively). However, the blood gas analysis variables of the cord blood did not show significant differences. Conclusions: Addition of fentanyl to bupivacaine was related to a longer sensory recovery time than did the addition of nothing or epinephrine. Moreover, it had been associated with beneficial effects such as a reduction in complications following spinal anesthesia. (Anesth Pain Med 2017; 12: 233-239)

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“…Previous results also suggested that intrathecal meperidine, in doses as low as 10 mg, could increase nausea or vomiting. (9,18). Increased nausea and vomiting may delay home discharge for outpatient surgery.…”

Section: Discussionmentioning

confidence: 99%

“…The aims of our study were to evaluate whether meperidine would prolong the duration of sensorial block as in conventional spinal anaesthesia (9) to prolong surgery duration and improve the feasibility of strict unilateral block.…”

Section: Introductionmentioning

confidence: 99%

Meperidine, as an Effective Adjuvant Agentin Unilateral Spinal Anaesthesia for Knee Arthroscopy

et al. 2008

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Aim: Unilateral spinal anaesthesia permits early recovery and short ambulatory stay. Our study aimed to search if meperidine may prolong sensory block time when added to hyperbaric bupivacaine.Methods: This is a prospective, double blinded study: Ambulatory, 46 consenting patients aged 18-60 years, undergoing unilateral knee arthroscopy were randomized in two groups. saline group (n=20): 1.3 ml of hyperbaric bupivacaine and 0.2 ml of serum physiologic was used. Meperidine group (n=20): 1.3 ml of hyperbaric bupivacaine and 0.2 ml of 5% meperidine was used. Sensory block times, duration of spinal anaesthesia, intraoperative adverse effects and patient satisfaction were recorded.Results: Mean duration of sensory block was greater in the meperidine group compared with the saline group. Strict unilateral block and hypotension were comparable among groups.Conclusion: Addition of meperidine to hyperbaric bupivacaine in unilateral spinal anaesthesia prolonged analgesia without effecting total anesthesia time with minimal adverse effects.

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Addition of meperidine to bupivacaine for spinal anaesthesia for Caesarean section†

Abstract: Addition of meperidine 10 mg to intrathecal bupivacaine for Caesarean section is associated with prolonged postoperative analgesia but with greater intraoperative nausea and vomiting.

Cited by 71 publications

References 22 publications

Analgesic Effects of Intrathecally Administered Fentanyl in Spinal Anaesthesia for Lower Limb Surgery

Analgesic Effects of Intrathecally Administered Fentanyl in Spinal Anaesthesia for Lower Limb Surgery

Beneficial effects of the addition of intrathecal fentanyl to bupivacaine for spinal anesthesia in cesarean section

Meperidine, as an Effective Adjuvant Agentin Unilateral Spinal Anaesthesia for Knee Arthroscopy

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