Addition of Monosodium Dihydrogen Phosphate to an Acid Concentrate to Prepare a Phosphate-Enriched, Bicarbonate-Based Hemodialysis Solution

Preventing/treating Hypophosphatemia by Adding Phosphate to the Dialysate

“…In vitro experiments have shown that one can introduce powder phosphate salts to either the acid or the base concentrate of a dual concentrate, bicarbonate-based dialysate delivery system (16–18). It is possible to use either: (a) a combination of monosodium dihydrogen phosphate monohydrate and disodium monohydrogen phosphate heptahydrate (16) or (b) monosodium dihydrogen phosphate monohydrate or disodium monohydrogen phosphate heptahydrate alone for the dialysate enrichment (17, 18). After the introduction of the above powder phosphate salts, vigorous shaking of the modified final dialysate concentrate is required to dissolve the added salts.…”