Addition of noradrenaline to intrathecal morphine augments the postoperative suppression of natural killer cell activity

Yokota, Tetsuya; Uehara, Kiyoshi; Nomoto, Y

doi:10.1007/s00540-004-0247-3

Cited by 31 publications

(20 citation statements)

References 24 publications

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“…11,39,40 In addition, IL-6 production remained significantly elevated compared with control values of healthy volunteers (0.22 Ϯ 0.005 ng/mL; P Ͻ 0.001). In contrast to other studies, which reported associations between the extent of surgery and peripheral and local IL-6 production when measured in the immediate postoperative period 41 and at 24 hours after surgery, 36 this study did not find such an association. However, similar to our results, Decker et al 42 demonstrated that IL-6 production was elevated up to 48 hours after abdominal surgery with a concomitant decrease in natural killer cells.…”

Section: Resultscontrasting

confidence: 86%

“…Acute pain is known to induce transient increases in NKCA. [31][32][33][34][35][36] Furthermore, laboratory models of stress have also demonstrated correlations between stress and increases in NKCA. 37,38 Discussion Neuroendocrine-immune alterations are well documented among surgical patients; however, little is known regarding the effect of perceive pain and stress on NKCA and IL-6 production in perioperative patients.…”

Section: Resultsmentioning

confidence: 99%

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Immune Function, Pain, and Psychological Stress in Patients Undergoing Spinal Surgery

Starkweather

Witek-Janusek

Nockels

et al. 2006

Spine

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Section: Resultscontrasting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Immune Function, Pain, and Psychological Stress in Patients Undergoing Spinal Surgery

Starkweather

Witek-Janusek

Nockels

et al. 2006

Spine

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“…Schiffman et al (21) also found that use of pleasant odors improved the mood of males at midlife in the POMS test. It has been reported that both adrenaline and noradrenaline inhibit human NK cell activity (22)(23). We found previously that physical and/or psychological stress decreased NK activity, NK receptor levels, and mRNA transcription of granzymes and perforin in mice (24).…”

Section: Effect Of Phytoncide Exposure On Adrenaline and Noradrenalinsupporting

confidence: 51%

Effect of Phytoncide from Trees on Human Natural Killer Cell Function

Kobayashi

Wakayama

et al. 2009

Int J Immunopathol Pharmacol

207

136

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We previously reported that the forest environment enhanced human natural killer (NK) cell activity, the number of NK cells, and intracellular anti-cancer proteins in lymphocytes, and that the increased NK activity lasted for more than 7 days after trips to forests both in male and female subjects. To explore the factors in the forest environment that activated human NK cells, in the present study we investigate the effect of essential oils from trees on human immune function in twelve healthy male subjects, age 37-60 years, who stayed at an urban hotel for 3 nights from 7.00p.m. to 8.00a.m. Aromatic volatile substances (phytoncides) were produced by vaporizing Chamaecyparis obtusa (hinoki cypress) stem oil with a humidifier in the hotel room during the night stay. Blood samples were taken on the last day and urine samples were analysed every day during the stay. NK activity, the percentages of NK and T cells, and granulysin, perforin, granzyme AlB-expressing lymphocytes in blood, and the concentrations of adrenaline and noradrenaline in urine were measured. Similar control measurements were made before the stay on a normal working day. The concentrations of phytoncides in the hotel room air were measured. Phytoncide exposure significantly increased NK activity and the percentages of NK, perforin, granulysin, and granzyme AlB-expressing cells, and significantly decreased the percentage of T cells, and the concentrations of adrenaline and noradrenaline in urine. Phytoncides, such as a-pinene and -pinene, were detected in the hotel room air. These findings indicate that phytoncide exposure and decreased stress hormone levels may partially contribute to increased NK activity.The forest environment has been enjoyed by humans for a long time because of the quiet atmosphere, beautiful scenery, mild climate, and clean fresh air. We previously reported that the forest environment enhanced human natural killer (NK) cell activity, the number of NK and NKT cells, and intracellular anti-cancer proteins in lymphocytes, and that the increased NK activity lasted for more than 7 days after the trips to forests both in male and female subjects (1-5). However, it is not clear what kind of factors in the forest environment activated human NK cells. We speculate that aromatic volatile substances derived from trees, including monoterpenes and sesquiterpenes, called phytoncides, such as a-pinene and limonene (6), may play an important role. Thus, the effects of phytoncides, such as a-pinene,

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“…Garland et al reported that adrenaline inhibits human NK activity [31]. The addition of noradrenaline to intrathecal morphine augments the postoperative suppression of NK cell activity [32], suggesting that noradrenaline also inhibits human NK activity. Li et al [33] reported that physical and/or psychological stress decreases NK activity, NK receptor levels, and mRNA transcription levels of granzymes and perforin in mice.…”

Section: Effect Of Forest Bathing Trips On Stress Hormonesmentioning

confidence: 98%

Effect of forest bathing trips on human immune function

2009

Environ Health Prev Med

408

268

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In Japan, a forest bathing trip, called "Shinrinyoku" in Japanese, is a short, leisurely visit to a forest; it is regarded as being similar to natural aromatherapy. This review focuses on the effects of forest bathing trips on human immune function. Beginning in 2005, adult Japanese individuals, both male and female, participated in a series of studies aimed at investigating the effect of forest bathing trips on human immune function. The subjects experienced a 3-day/2-night trip to forest areas, and blood and urine were sampled on days 2 (the first sampling during each trip) and 3 (the second sampling during each trip), and on days 7 and 30 after the trips. Natural killer (NK) activity, the numbers of NK, granulysin-, perforin-, and granzymes A/B-expressing lymphocytes in the blood, and the concentration of urinary adrenaline were measured. The same measurements were made before the trips on a normal working day as a control. The mean values of NK activity and the numbers of NK, granulysin-, perforin-, and granzymes A/B-expressing cells on forest bathing days were significantly higher than those on the control days, whereas the mean values of the concentration of urinary adrenaline on forest bathing days were significantly lower than that on the control days in both male and female subjects. The increased NK activity lasted for more than 30 days after the trip, suggesting that a forest bathing trip once a month would enable individuals to maintain a higher level of NK activity. In contrast, a visit to the city as a tourist did not increase NK activity, the numbers of NK cells, or the level of intracellular granulysin, perforin, and granzymes A/B. These findings indicate that forest bathing trips resulted in an increase in NK activity, which was mediated by increases in the number of NK cells and the levels of intracellular granulysin, perforin, and granzymes A/B.

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Addition of noradrenaline to intrathecal morphine augments the postoperative suppression of natural killer cell activity

Abstract: Intrathecal administration of morphine causes a decrease in NK cell activity, and its combined use with noradrenaline prolongs the suppression of NK cell activity.

Cited by 31 publications

References 24 publications

Immune Function, Pain, and Psychological Stress in Patients Undergoing Spinal Surgery

Immune Function, Pain, and Psychological Stress in Patients Undergoing Spinal Surgery

Effect of Phytoncide from Trees on Human Natural Killer Cell Function

Effect of forest bathing trips on human immune function

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