Addition of Orange Pomace to Orange Juice Attenuates the Increases in Peak Glucose and Insulin Concentrations after Sequential Meal Ingestion in Men with Elevated Cardiometabolic Risk

Abstract

OPF consumed with breakfast may lower postprandial glycemic and insulinemic responses to typical meal ingestion in men with increased cardiometabolic risk. This trial is registered at clinicaltrials.gov as NCT01963416.

An Overview of Novel Dietary Supplements and Food Ingredients in Patients with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease

“…Moreover, similar effects on metabolism were observed with other natural products, such as grape [ 72 , 73 , 74 ], green tea [ 75 , 76 , 77 , 78 , 79 ], orange juice [ 80 , 81 , 82 , 83 ], hibiscus [ 84 , 85 , 86 ], Aloe vera [ 87 ], Wild bitter [ 88 ] and berberine or barberry [ 89 , 90 ]. In turn, these food ingredients have been related to health promotion, chronic disease prevention, and adjunctive therapy in individuals with MetS and NAFLD.…”

“…Despite this high presence of sugar in pure OJ, particular phenolic compounds and flavonoids present in OJ protected individuals from metabolic disturbances. As such, some studies investigated the correlation between OJ consumption and the improvement of metabolic syndrome parameters [ 80 , 81 , 82 , 83 ].…”

“…In addition, a prospective cohort study observed that 240 mL OJ and 5.5 g orange pomace (OPF) altered the time course of glucose and insulin responses after a high-fat meal, which reduced the postprandial glycemic and insulinemic responses in men ( n = 36) with high cardiovascular risk. Together with these findings, OPF was able to lower non-esterified fatty acid (NEFA) concentrations circulating between 120 and 420 min after a high-fat meal, aligning with a potential impact on glucose metabolism [ 82 ]. High concentrations of NEFA were suggested to impair glucose metabolism by elevating β-oxidation in some peripheral tissues and by competing with glucose for oxidation, thus suppressing glucose metabolism through the inhibition of glucose transporter type 4 (GLUT4), leading to a reduction in peripheral glucose [ 129 , 130 ].…”

Effect of Fibre-Enriched Orange Juice on Postprandial Glycaemic Response and Satiety in Healthy Individuals: An Acute, Randomised, Placebo-Controlled, Double-Blind, Crossover Study

“…It has been proposed that high viscous fibre can lead to a decrease in postprandial glycaemia and insulin response [17], while the effect of soluble fibre on fasting glucose and insulin levels has been demonstrated in overweight adults [18]. Several acute and chronic studies have used fruit juice as a matrix for fibre enrichment, obtaining remarkable effects on the postprandial glycaemic response of both healthy subjects and men with metabolic risk when doses of fibre were moderately high [19][20][21][22]. However, there is little evidence of the effect of dietary fibre intake on glycaemic profile, satiety and the secretion of GI hormones on a healthy adult population in the case of non-sweetened fruit juice enriched with an extract of the fruit's own fibre (albedo and flavedo obtained from the orange peel), a novel by-product of orange juice production composed of different types of soluble and insoluble fibre.…”

A comparative assess of high hydrostatic pressure and superfine grinding on physicochemical and antioxidant properties of grape pomace

“…Dietary fibre is also abundant in grape pomace (Monro et al, 2016). A lot of studies have revealed that it might be involved in disease prevention and health promotion, including attenuation of blood cholesterol and glucose (Dong et al, 2016), laxative effect (Bliss et al, 2014) and reduction of risk in colon cancer (Vulcan et al, 2015), heart disease (Kim & Je, 2016) and obesity (Han et al, 2015). Therefore, it is of greater importance for full utilisation of grape pomace in order to turn environmental waste into high-value products.…”