Addition of peroxiredoxin 6 (PRDX6) to IVF fertilization medium maintains motility and longevity of human spermatozoa

Sun, Tie-Cheng; Yan-dong, Zhang; Li, Jianhua; Yu, Haiyang; Song, Lijin; Sun, Xinping; Chen, Xi; Tian, Li

doi:10.32604/biocell.2021.014694

Biocell

2021

DOI: 10.32604/biocell.2021.014694

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Addition of peroxiredoxin 6 (PRDX6) to IVF fertilization medium maintains motility and longevity of human spermatozoa

Tie-Cheng Sun¹,

Zhang Yan-dong²,

Jianhua Li³

et al.

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2023

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Cited by 1 publication

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Heat exposure promotes apoptosis and pyroptosis in Sertoli cells

WANG¹,

He²,

Gao³

et al. 2023

Biocell

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Heat stress is an important influence on the male reproductive organs. Therefore, the effects of heat stress on genes or pathways related to the reproductive system of male mice were experimentally explored in this paper to further determine the effects of heat stimulation on mammals. Herein, models of heat-exposed mouse testicular tissue and heatexcited cells were successfully established. Many scorched vesicles were found after heat excitation of testis supporting cells, testicular mesenchymal (TM4) cells. Western blot, in situ terminal deoxynucleotide transferase dUTP Nick end labeling (TUNEL) and transmission electron microscopy showed that membrane rupture, mitochondrial damage and autophagic vesicles occurred in TM4 cells after thermal excitation. The N-segment fragment of the associated protein shear was increased, and the TUNEL result was positive. In conclusion, thermal excitation induced apoptosis and scorch death in TM4 cells. Thus, the Hippo pathway and apoptosis-related pathway were significantly enriched after heat stimulation in mouse testis, and the scorch death effect in TM4 cells was induced by heat excitation.

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Heat exposure promotes apoptosis and pyroptosis in Sertoli cells

WANG¹,

He²,

Gao³

et al. 2023

Biocell

View full text Add to dashboard Cite

show abstract

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Addition of peroxiredoxin 6 (PRDX6) to IVF fertilization medium maintains motility and longevity of human spermatozoa

Cited by 1 publication

References 18 publications

Heat exposure promotes apoptosis and pyroptosis in Sertoli cells

Heat exposure promotes apoptosis and pyroptosis in Sertoli cells

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