Addition of Salmeterol versus Doubling the Dose of Beclomethasone in Children with Asthma

Verberne, A.A.P.H.; Frost, Chris; Duiverman, Eric J.; Grol, Marion H.; Kerrebijn, K. F.

doi:10.1164/ajrccm.158.1.9706048

Cited by 200 publications

(149 citation statements)

References 29 publications

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“…For all children, but particularly for those aged f5 yrs, combination therapy has been less well studied, and the addition of a long-acting b 2 -agonist may not be as effective as increasing the dose of inhaled glucocorticosteroids in reducing exacerbations [182,291,292]. However, the interpretation of some studies is problematic, as not all children received concurrent inhaled glucocorticosteroids [182,291].…”

Section: Treatment Steps For Achieving Controlmentioning

confidence: 99%

Global strategy for asthma management and prevention: GINA executive summary

Bateman

Ss²,

Barnes³

et al. 2007

Eur Respir J

2,663

2,301

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Asthma is a serious health problem throughout the world. During the past two decades, many scientific advances have improved our understanding of asthma and ability to manage and control it effectively. However, recommendations for asthma care need to be adapted to local conditions, resources and services. Since it was formed in 1993, the Global Initiative for Asthma, a network of individuals, organisations and public health officials, has played a leading role in disseminating information about the care of patients with asthma based on a process of continuous review of published scientific investigations. A comprehensive workshop report entitled ''A Global Strategy for Asthma Management and Prevention'', first published in 1995, has been widely adopted, translated and reproduced, and forms the basis for many national guidelines. The 2006 report contains important new themes. First, it asserts that ''it is reasonable to expect that in most patients with asthma, control of the disease can and should be achieved and maintained,'' and recommends a change in approach to asthma management, with asthma control, rather than asthma severity, being the focus of treatment decisions. The importance of the patient-care giver partnership and guided self-management, along with setting goals for treatment, are also emphasised.

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Section: Treatment Steps For Achieving Controlmentioning

confidence: 99%

Global strategy for asthma management and prevention: GINA executive summary

Bateman

Ss²,

Barnes³

et al. 2007

Eur Respir J

2,663

2,301

View full text Add to dashboard Cite

show abstract

“…Verberne et al showed in a prospective randomised controlled study that children with moderate severe asthma did not benefit from doubling their dose of ICS, or from addition of a LABA to their ICS. 17 Some authors have even suggested a worsening of asthma control by treatment with the combination of an ICS and a LABA. Bisgaard found that the relative risk of an asthma exacerbation as well as the risk of hospitalisation for asthma was increased for children using additional LABA compared to regular maintenance therapy with ICS; 18 he concluded that the lack of evidence for the control of asthma exacerbations in children regularly using a LABA should bring into question its general use as add-on therapy.…”

Section: Discussionmentioning

confidence: 99%

Children with asthma on inhaled corticosteroids managed in general practice or by hospital paediatricians: is there a difference?

Kuethe

Vaessen-Verberne

Bindels

et al. 2009

Primary Care Respiratory Journal

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Aim: To investigate whether there are differences in asthma characteristics between two populations of children with moderate asthma requiring inhaled corticosteroids (ICS) who are treated in general practice or in hospital practice.Patients and Methods: 45 children from general practice and 62 from hospital practice, diagnosed with asthma and treated with ICS, were analysed in terms of lung function parameters, asthma control (ACQ), and use of medication.Results: Children in general practice did not differ significantly from those in paediatric practice with respect to mean age, lung function tests, and corrected daily dose of ICS. The median ACQ score was higher (representing poorer control) in the general practice group than in the paediatric practice group (0.67 and 0.33 respectively, p < 0.05). Fewer children (22.7%) from the general practice group than from the paediatric group (98.4%) had planned review visits (p< 0.01). Prescriptions for a combination ICS/long-acting β2-agonist (LABA) inhaler were 28.9% in the general practice group and 6.5% in the paediatric group (p<0.05). Conclusion:The hospital-based group was better controlled with less frequent use of combination therapy. Our observations stress the necessity for regular review visits for children with moderately severe asthma especially in general practice.

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“…In children, the preferred option is to increase ICS to medium dose (see Box 3-6, p.44), 172 and in this age group, the effect may be similar to 173 or more effective 174,175 than adding LABA.…”

Section: Preferred Option (Adults/adolescents): Combination Low Dose mentioning

confidence: 99%

Mortality in Asthma-Chronic Obstructive Pulmonary Disease Overlap in the United States

Kumbhare

Strange

2018

Southern Medical Journal

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Addition of Salmeterol versus Doubling the Dose of Beclomethasone in Children with Asthma

Cited by 200 publications

References 29 publications

Global strategy for asthma management and prevention: GINA executive summary

Global strategy for asthma management and prevention: GINA executive summary

Children with asthma on inhaled corticosteroids managed in general practice or by hospital paediatricians: is there a difference?

Mortality in Asthma-Chronic Obstructive Pulmonary Disease Overlap in the United States

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