Addition of Sulfur Trioxide to Pentafluorothio (SF<sub>5</sub>) (Pentafluoro‐λ<sup>6</sup>‐Sulfanyl) Containing Fluoroolefins

Mohtasham, J.; Terjeson, Robin J.; Gard, Gary L.; Scott, Robert A.; Madappat, Krishnan V.; Thrasher, Joseph S.

doi:10.1002/9780470132609.ch12

Cited by 8 publications

(59 citation statements)

References 6 publications

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“…Both in SF 6 and in SF 5 -compounds the sulfur atom is in hypervalent hexacoordinated state with an octahedral geometry of the ligands. The pentafluorosulfanyl group has remarkable chemical stability and compounds incorporating this group often possess advantageous and interesting properties, including high thermal, hydrolytic and chemical stability, high density, high lipophilicity and biological activity [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…inorganic SF 5 -chemistry and SF 5 -substituted polymers will not be discussed. The review is structured in three main sections: (1) Synthesis of SF 5 containing molecules (primary reactivity); (2) Reactions of SF 5 -containing molecules (secondary reactivity); (3) Biological properties. Different aspects of the chemistry and properties of SF 5 compounds have been reviewed, mainly in book chapters [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…This review article is focused on small organic molecules having an SF 5 -carbon bond, i.e. inorganic SF 5 -chemistry and SF 5 -substituted polymers will not be discussed. The review is structured in three main sections: (1) Synthesis of SF 5 containing molecules (primary reactivity); (2) Reactions of SF 5 -containing molecules (secondary reactivity); (3) Biological properties.…”

Section: Introductionmentioning

confidence: 99%

“…The review is structured in three main sections: (1) Synthesis of SF 5 containing molecules (primary reactivity); (2) Reactions of SF 5 -containing molecules (secondary reactivity); (3) Biological properties. Different aspects of the chemistry and properties of SF 5 compounds have been reviewed, mainly in book chapters [4][5][6][7][8][9]. To our knowledge the most recent general review covering SF 5 -compounds dates back to 2005 [10] and comprehensively covers the literature until 2000, with scattered references to articles published in the following two years.…”

Section: Introductionmentioning

confidence: 99%

“…Pentafluorosulfanyl (SF 5 ) compounds are considered to be organic derivatives of sulfur hexafluoride SF 6 . Both in SF 6 and in SF 5 -compounds the sulfur atom is in hypervalent hexacoordinated state with an octahedral geometry of the ligands.…”

Section: Introductionmentioning

confidence: 99%

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Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules

Zanda

Altomonte

2012

Journal of Fluorine Chemistry

198

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The pentafluorosulfanyl group (SF5) is a highly stable chemical function which has been attracting a great deal of interest owing to its peculiar chemical, structural, physicochemical and biological properties. Progress in the area of SF5-compounds has been somewhat hindered by the lack of straightforward lab-scale synthetic methods for introducing the SF5-group into organic molecules. However, recent synthetic progress, the availability of some SF5-building blocks from commercial suppliers and the discovery of interesting properties of SF5-substituted molecules in materials science, biology and drug discovery are giving new momentum to research in this fascinating area of fluorine chemistry. Synthesis, reactivity and biological properties of SF5-substituted organic molecules are herein reviewed with an emphasis on the work published after year 2000. Object *Cover Letter or Page containing Author DetailsAll of the referees' suggestions have been accepted, with the only exception of Referee's 2 point 5 "Reactions of ArylSF5 systems should be divided into sections …electrophilc substitutions, nucleophilic substitutions, reactions of diazo systems,…" because in that section the chemistry is inherently heterogeneous and we feel that such a subclassification would be very challenging to achieve and would make less homogeneous the discussion of the topic. Molecolare, via Mancinelli 7, 20131 Milano, Italy Synthesis, reactivity and biological properties of SF 5 -substituted organic molecules are reviewed in this article, with an emphasis on the work published in the last decade. *Graphical Abstract -Synopsis Highlights We review the synthesis of SF 5 -compounds, with an emphasis on work published after year 2000.  We review the reactivity of SF 5 -substituted organic molecules.  We review the biological properties of SF 5 -substituted drug candidates. Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK; e-mail: m.zanda@abdn.ac.uk b C.N.R.-Istituto di Chimica del Riconoscimento Molecolare, via Mancinelli 7, 20131 Milano, Italy AbstractThe pentafluorosulfanyl group (SF 5 ) is a highly stable chemical function which has been attracting a great deal of interest owing to its peculiar chemical, structural, physicochemical and biological properties. Progress in the area of SF 5 -compounds has been somewhat hindered by the lack of straightforward lab-scale synthetic methods for introducing the SF 5 -group into organic molecules. However, recent synthetic progress, the availability of some SF 5 -building blocks from commercial suppliers and the discovery of interesting properties of SF 5 -substituted molecules in materials science, biology and drug discovery are giving new momentum to research in this fascinating area of fluorine chemistry. Synthesis, reactivity and biological properties of SF 5 -substituted organic molecules are herein reviewed with an emphasis on the work published after year 2000.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules

Zanda

Altomonte

2012

Journal of Fluorine Chemistry

198

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Lithium salts of SF5 alkylsulfonic acids: synthesis, characterization and conductivity

Hamel

Nixon

Gard

et al. 1996

Journal of Fluorine Chemistry

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Four-membered Rings with One Oxygen and One Sulfur Atom

Buglass

1996

Comprehensive Heterocyclic Chemistry II

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Addition of Sulfur Trioxide to Pentafluorothio (SF₅) (Pentafluoro‐λ⁶‐Sulfanyl) Containing Fluoroolefins

Cited by 8 publications

References 6 publications

Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules

Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules

Lithium salts of SF5 alkylsulfonic acids: synthesis, characterization and conductivity

Four-membered Rings with One Oxygen and One Sulfur Atom

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Addition of Sulfur Trioxide to Pentafluorothio (SF5) (Pentafluoro‐λ6‐Sulfanyl) Containing Fluoroolefins

Cited by 8 publications

References 6 publications

Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules

Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules

Lithium salts of SF5 alkylsulfonic acids: synthesis, characterization and conductivity

Four-membered Rings with One Oxygen and One Sulfur Atom

Contact Info

Product

Resources

About

Addition of Sulfur Trioxide to Pentafluorothio (SF₅) (Pentafluoro‐λ⁶‐Sulfanyl) Containing Fluoroolefins