Additional antiprotozoal constituents from <i>Cuphea pinetorum</i>, a plant used in Mayan traditional medicine to treat diarrhoea

Calzada, Fernando

doi:10.1002/ptr.1717

Cited by 44 publications

(38 citation statements)

References 9 publications

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“…Numerous plants store highly active compounds in the leaves, the most important plant part in the present study, and these compounds confer significant antibacterial and antioxidant effects [54][55][56]. Teas containing infusions are among the most common medicinal preparations globally.…”

Section: Discussionmentioning

confidence: 99%

An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

et al. 2018

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Despite the fact that Mexico has vast biocultural biodiversity, there are numerous regions where the traditional medicinal use of plants has not yet been studied. We aimed to document, analyze quantitatively, and preserve medicinal plant knowledge among local people living in over 40 communities in the state of Zacatecas. Ethnobotanical information was collected by semistructured interviews with 132 informants. Data were analyzed using standard quantitative indices such as relative frequency of citation, family importance value, cultural importance index, and informant consensus factor. We recorded 168 medicinal plant taxa belonging to 151 genera and 69 botanical families and used to treat 99 health disorders. The most medicinally important plant families were Asteraceae (20 species), followed by Fabaceae and Lamiaceae (12 species) and Cactaceae (five species). The most culturally important species was Matricaria chamomilla L., mentioned 140 times, followed by Arnica montana L. (62 times) and Artemisia ludoviciana Nutt (48 times). The highest consensus for use was for diseases of the reproductive system. The type of disorder for which there was the highest number of references for use (389; 25% of all uses) and plant species (67) were diseases of the digestive and gastrointestinal system. The present study represents the first quantitative medical-ethnobotanical documentation and analysis of the traditional use of medicinal plants in Zacatecas state. Despite the semiarid climate, this region is botanically highly diverse, and its flora have versatile medicinal uses.

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Section: Discussionmentioning

confidence: 99%

An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

et al. 2018

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“…In highly uneducated societies, like Pakistan, where literacy rate is 34% and only 20% population has access to safe water supply and sanitation and even lesser in the rural area, the prevalence of parasitic infection is a common problem (Iliyas, 2006) which requires effective treatment. Many options exist for the treatment of parasitic infection including herbal medicine, which are said to be more cost effective with less side effects (Dans, 2007;Shahab-uddin, 2006;Al-Habbal, 1984;Calzada, 2005). Some work has been done regarding the prevalence of HIPP in Pakistan but there were few studies conducted to compare allopathic and herbal modalities for the treatment of amoebiasis (Khan, 2008;Ranque, 2004).…”

Section: Human Intestinal Pathogenic Parasites (Hipp) Especiallymentioning

confidence: 99%

Comparison of allopathic and herbal medicine for the treatment of Entamoeba histolytica: A double blind clinical trial

Siddiqui¹,

Usmanghani²

2015

J. Med. Plants Res.

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This parallel, randomized, double blind clinical trial was designed to compare allopathic drugs [a combination of metronidazole + diloxanide furoate (MDF)] with Endemali (herbal product) for therapeutic cure rate and side effects in order to find out the most suitable drug for this killer disease. This double blind randomized clinical trial was conducted in two areas of Karachi, Pakistan after approval from ethical committee of Hamdard University. All those confirmed for Entamoeba histolytica were included in the study. One hundred and seventy one patients selected for the study were randomly allocated to two arms of 86 and 85 for allopathic and herbal treatment, respectively. However 78 in allopathic and 75 in herbal group completed the study. Main outcome variable was treatment success or failure. Secondary outcome measures included side effects and association with age and sex. No significant difference was observed in the socio economic and demographic variables at the baseline. No significant difference was found between the cure rate of MDF and Endemali; hence both drugs were equally effective in treating amoebiasis. Significant differences were reported for the side effects observed among the two groups and the price. The failure rate for the two drugs was 28.7%. It is concluded that both Endemali and MDF are equally effective in treating amoebiasis. However, Endemali has fewer side effects than MDF. New drugs need to be researched for the treatment of E. histolytica because of high failure rate of the two drugs against this killer organism.

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“…The results showed that 21 (twenty-one) methanolic extracts obtained from the species studied brought about death or growth inhibition in trophozoites of Giardia lamblia. Aside from the scarce investigation of the giardicidal activity of extracts and fractions carried out in Africa, Brazil, China, Cuba, India, USA, Malaysia, Venezuela and Thailand, the largest contribution to this area of study has come from Mexico, where numerous plant species are used in popular medicine for the treatment of gastrointestinal illnesses, which has in turn stimulated validation studies (Calzada et al, 1998b;1999b;2005;2006;Ponce-Macotela et al, 2001;TapiaPérez et al, 2003;Peraza-Sánchez et al, 2005).…”

Section: Giardicidal Activity Of Plant Extracts and Fractionsmentioning

confidence: 99%

“…Formononetin, an isofl avone isolated from Dalbergia frutescens, exhibited intense activity with an IC 50 below that of metronidazole ® , the reference drug for the giardiasis treatment and employed as a positive control in the assays (Khan et al, 2000). Eleven compounds, including fl avonoids, steroids and triterpenes were isolated from the genus Geranium, represented by the species Geranium mexicanum and Geranium niveum (Calzada et al, 1999a;2001b;2005).…”

Section: Giardicidal Activity Of Chemically Defi Ned Moleculesmentioning

confidence: 99%

“…Bruceantin, (-)-epicatechin, β-sitosterol, β-sitosterol 3-O-β-D-glucopyranoside, hyperin, kaempferol, narcissin, quercetin and rutin are examples of compounds isolated from distinct plant species whose activity has been examined in vitro against different strains of Giardia lamblia by various authors (Gillin et al, 1982;Wright et al, 1993a;Calzada et al, 1999a;1999b;2001a;2003;2005;Calzada 2005;Arrieta et al, 2001;Alanís et al, 2003).…”

Section: Giardicidal Activity Of Chemically Defi Ned Moleculesmentioning

confidence: 99%

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Plants and chemical constituents with giardicidal activity

Amaral¹,

Ribeiro²,

Barbosa-Filho³

et al. 2006

Rev. bras. farmacogn.

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RESUMO: "Plantas e constituintes químicos com atividade giardicida". Infecção intestinal causada por Giardia lamblia representa grave problema de saúde pública, com elevadas taxas de prevalência em diversos países. O aumento de resistência do parasita e os efeitos colaterais dos fármacos de referência empregados no tratamento da giardíase, tornam necessário a busca de novos agentes terapêuticos. Produtos naturais, especialmente de origem vegetal, representam excelentes fontes de pesquisas. Este trabalho tem como objetivo revisar a literatura de extratos de plantas, frações e compostos químicos com estudos in vitro de avaliação da atividade giardicida. A revisão refere 153 (cento e cinqüenta e três) espécies vegetais de 69 (sessenta e nove) famílias que foram submetidas à avaliação da atividade giardicida. Descreve a distribuição geográfi ca das espécies vegetais, parte usada, preparação, cepa de Giardia lamblia testada e resultados por autores. Apresenta 101 (cento e um) compostos isolados de espécies vegetais classifi cados por classes químicas. Discute aspectos recentes da pesquisa de produtos naturais de origem vegetal empregados no tratamento da giardíase.Unitermos: Giardia lamblia, atividade giardicida, produtos naturais, plantas medicinais, revisão. ABSTRACT:Intestinal infection caused by Giardia lamblia represents a serious public health problem, with increased rates of prevalence in numerous countries. Increased resistance of the parasite and the side-effects of the reference drugs employed in the treatment of giardiasis make necessary to seek new therapeutic agents. Natural products, especially of plant origin, represent excellent starting point for research. The objective of this study is to review the literature on plant extracts, fractions and chemical constituents whose giardicidal activity has been investigated in vitro. The review describes 153 (one hundred and fi fty-three) plant species from 69 (sixty-nine) families that were evaluated for their giardicidal activity. The geographical distribution of the plant species, the part used, preparation, strain of Giardia lamblia tested and the results obtained by the authors are also given. One hundred and one compounds isolated from plant species, classifi ed by chemical class, are presented. Recent aspects of research on natural products of plant origin employed in the treatment of giardiasis are also discussed.

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Additional antiprotozoal constituents from Cuphea pinetorum, a plant used in Mayan traditional medicine to treat diarrhoea

Cited by 44 publications

References 9 publications

An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

Comparison of allopathic and herbal medicine for the treatment of Entamoeba histolytica: A double blind clinical trial

Plants and chemical constituents with giardicidal activity

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