Additional direct medical costs of nosocomial infections: an estimation from a cohort of patients in a French university hospital

Defez, C.; Fabbro‐Peray, Pascale; Cazaban, M.; Boudemaghe, Thierry; Sotto, Albert; Daurès, Jean‐Pierre

doi:10.1016/j.jhin.2007.11.005

Cited by 69 publications

(55 citation statements)

References 21 publications

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“…The situation is further complicated by the development of multiple antibiotic resistance among bacteria associated with nosocomial infections. 5,6 Advances in the field of nanotechnology have motivated scientists to develop innovative strategies to utilize nanomaterials that not only effectively control bacterial infections but can also mitigate their toxins.…”

Section: Introductionmentioning

confidence: 99%

Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control

Lambadi¹,

Sharma²,

Kumar³

et al. 2015

IJN

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Infectious diseases cause a huge burden on healthcare systems worldwide. Pathogenic bacteria establish infection by developing antibiotic resistance and modulating the host’s immune system, whereas opportunistic pathogens like Pseudomonas aeruginosa adapt to adverse conditions owing to their ability to form biofilms. In the present study, silver nanoparticles were biofunctionalized with polymyxin B, an antibacterial peptide using a facile method. The biofunctionalized nanoparticles (polymyxin B-capped silver nanoparticles, PBSNPs) were assessed for antibacterial activity against multiple drug-resistant clinical strain Vibrio fluvialis and nosocomial pathogen P. aeruginosa . The results of antibacterial assay revealed that PBSNPs had an approximately 3-fold higher effect than the citrate-capped nanoparticles (CSNPs). Morphological damage to the cell membrane was followed by scanning electron microscopy, testifying PBSNPs to be more potent in controlling the bacterial growth as compared with CSNPs. The bactericidal effect of PBSNPs was further confirmed by Live/Dead staining assays. Apart from the antibacterial activity, the biofunctionalized nanoparticles were found to resist biofilm formation. Electroplating of PBSNPs onto stainless steel surgical blades retained the antibacterial activity against P. aeruginosa . Further, the affinity of polymyxin for endotoxin was exploited for its removal using PBSNPs. It was found that the prepared nanoparticles removed 97% of the endotoxin from the solution. Such multifarious uses of metal nanoparticles are an attractive means of enhancing the potency of antimicrobial agents to control infections.

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Section: Introductionmentioning

confidence: 99%

Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control

Lambadi¹,

Sharma²,

Kumar³

et al. 2015

IJN

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“…Another two studies estimated an additional cost per patient of US$ 5,000.00 for treatment of infected total knee arthroplasty 7 and of US$ 2,867.50 per patient with SSI in general. 16 Most studies carried out to evaluate the economic impact of SSIs have used length of hospital stay as an indicator for the costs required for such infections. In studies conducted in different occasions between the 1950's and the beginning of the 1980's, the additional hospital stay attributed to SSIs was estimated to be between seven and 24 days.…”

Section: Discussionmentioning

confidence: 99%

Economic impact of treatment for surgical site infections in cases of total knee arthroplasty in a tertiary public hospital in Brazil

Dal-Paz¹,

Oliveira²,

Paula³

et al. 2010

Braz J Infect Dis

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We declare no confl ict of interest. ABSTRACTThe aim of this study was to estimate the additional cost of treatment of a group of nosocomial infections in a tertiary public hospital. A retrospective observational cohort study was conducted by means of analyzing the medical records of 34 patients with infection after total knee arthroplasty, diagnosed in 2006 and 2007, who met the criteria for nosocomial infection according to the Centers for Disease Control and Prevention. To estimate the direct costs of treatment for these patients, the following data were gathered: length of hospital stay, laboratory tests, imaging examinations, and surgical procedures performed. Their costs were estimated from the minimum values according to the Brazilian Medical Association. The estimated cost of the antibiotics used was also obtained. The total length of stay in the ward was 976 days, at a cost of US$ 18,994.63, and, in the intensive care unit, it was 34 days at a cost of US$ 5,031.37. Forty-two debridement procedures were performed, at a cost of US$ 5,798.06, and 1965 tests (laboratory and imaging) were also performed, at a cost of US$ 15,359.25. US$ 20,845.01 was spent on antibiotics and US$ 1,735.16 on vacuum assisted closure therapy, microsurgical fl aps, implant removal, spacer use, and surgical revision. The total additional cost of these cases of hospital infection in 2006 and 2007 was of US$ 91,843.75. Based on that, we demonstrate that the high cost of treatment for hospital infections emphasizes the importance of taking measures to prevent and control hospital infection.

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“…Prolonged hospitalization alone accounted for 69% of the total charges [3]. The importance of nosocomial infections to public health and healthcare costs, as well as the increasing concern around the growth of antibiotic resistance, has led to a number of prevention efforts and recommendations [4].…”

Section: Introductionmentioning

confidence: 99%

Healthcare Resource Utilization and Cost Related to Nosocomial Pneumonia Caused by Staphylococcus aureus and Pseudomonas aeruginosa in France: A 2010-2011 Population-Based Cohort Study Using a National Claims Database

Toussi¹,

Bardoulat²,

Jafri³

et al. 2017

Epidemiology

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Additional direct medical costs of nosocomial infections: an estimation from a cohort of patients in a French university hospital

Cited by 69 publications

References 21 publications

Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control

Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control

Economic impact of treatment for surgical site infections in cases of total knee arthroplasty in a tertiary public hospital in Brazil

Healthcare Resource Utilization and Cost Related to Nosocomial Pneumonia Caused by Staphylococcus aureus and Pseudomonas aeruginosa in France: A 2010-2011 Population-Based Cohort Study Using a National Claims Database

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