Additional malignancies in patients with gastrointestinal stromal tumors (GIST): incidence, pathology and prognosis according to a time of occurrence-based classification

Association Between Gastrointestinal Stromal Tumors and Other Malignancies: It Is Only a Matter of Time ? A Case Series and an Overview of Systematic Reviews

“…The frequency of synchronous or metachronous SPTs in patients with GIST, is widely variable among different studies published in the literature [11,13,14,16]. In the present study, a frequency of 17.9% has been detected, while our overview of systematic reviews shows that the cumulative prevalence rate of SPTs ranges from 9.3% in the study by Agaimy et al [7] to 18.0% in the study by Diamantis et al [24], with a mean prevalence rate of 14.5%.…”

“…Main study findings showed that in 41.2% of patients the diagnosis of both GIST and SPT was synchronic. In 23.5% of cases, the associated tumors were diagnosed before GIST, in 35.2% of cases were diagnosed after GIST, and in 2.9% of cases SPTs were diagnosed as synchronous associated neoplasm during GIST staging [11].…”

“…The series of patients was divided into two groups: isolated GIST (group A) and GIST associated with SPT (group B). Group A patients were further classified into four subgroups, in accordance with the classification proposed by Fernandez et al [11]: type 1s (diagnosis of GIST first and synchronous associated neoplasm during GIST staging or intraoperative finding), type 1m (diagnosis of GIST first and metachronous associated neoplasm, diagnosed during GIST follow-up), type 2s (synchronous incidental GIST diagnosed during the staging of associated tumor or intraoperatively), and type 2m (metachronous GIST diagnosed during associated tumor follow-up). Follow-up was obtained either in outpatient clinic or by mean of telephone calls.…”

“…Outside of these syndromic forms, little is known about the sporadic coexistence of GISTs with SPTs, although multiple single institution and population-based studies have reported GIST patients to have an increased risk of presenting with additional malignancies, either synchronously or during follow-up [7,[11][12][13][14].…”

Association of Genitourinary Cancer Among Patients with Gastrointestinal Stromal Tumor: A Unique Pattern in a Tertiary Care Saudi Cohort

“…The reported prevalence of genitourinary cancer associated with GIST is 3-15.6% (Table 2) [7][8][9][10][11][12][13][14][15][16][17]. Prostatic adenocarcinoma is the most common primary genitourinary cancer (2.9-9%), followed by RCC (0.6-11.4%) [7][8][9][10][11][12][13][14][15][16][17]. Rarely seminoma [7,11,16] and a single case of adrenal neuroblastoma were reported [12].…”