Additional risk factor for the development of ALL

Pietrzyk, Jacek J; Madetko‐Talowska, Anna; Bik-Multanowski, Mirosław; Oltarzewski, Mariusz

doi:10.1002/pbc.22080

Pediatric Blood & Cancer

2009

DOI: 10.1002/pbc.22080

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Additional risk factor for the development of ALL

Jacek J Pietrzyk

Anna Madetko‐Talowska

Mirosław Bik-Multanowski

et al.

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2015

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Association between MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Meta-Analysis Based on 51 Case-Control Studies

Liang

et al. 2015

Med Sci Monit

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BackgroundStudies and systematic reviews have reached inconsistent conclusions on the role of 5, 10-methylenetetrahydrofolate reductase (MTHFR) polymorphism C677T in acute lymphoblastic leukemia (ALL) risk.Material/MethodsThe present meta-analysis comprising of 51 case-control studies, including 7892 cases and 14 280 controls was performed to reevaluate the association between MTHFR C677T polymorphism and ALL risk.ResultsStatistical differences were found in the dominant model (TT+CT vs. CC, odd ratio (OR)=0.89, 95% CI, 0.79–1.00, P=0.04) and the CT vs. CC (OR=0.89, 95% CI, 0.80–1.00, P=0.05), but not in the allele contrast model (T vs. C, OR=0.92, 95% CI, 0.84–1.01, P=0.08), additive model (TT vs. CC, OR=0.87, 95% CI, 0.73–1.05, P=0.15), or recessive model (TT vs. CT+CC, OR=0.94, 95% CI, 0.81–1.10, P=0.44) in overall populations. In the subgroup analyses stratified by age (children and adults) and ethnicity (Asian and Caucasian), no significant associations between MTHFR C677T polymorphism and ALL risk were observed.ConclusionsThe current study found no sufficient evidence of a protective role of MTHFR C677T polymorphism in ALL susceptibility.

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Association between MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Meta-Analysis Based on 51 Case-Control Studies

Liang

et al. 2015

Med Sci Monit

View full text Add to dashboard Cite

show abstract

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Additional risk factor for the development of ALL

Cited by 1 publication

References 4 publications

Association between MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Meta-Analysis Based on 51 Case-Control Studies

Association between MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Meta-Analysis Based on 51 Case-Control Studies

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