Additional taxonomic coverage of the doubly uniparental inheritance in bivalves: Evidence of sex‐linked heteroplasmy in the razor clam
            <i>Solen marginatus</i>
            Pulteney, 1799, but not in the lagoon cockle
            <i>Cerastoderma glaucum</i>
            (Bruguière, 1789)

Lucentini, Livia; Plazzi, Federico; Sfriso, A.; Pizzirani, Claudia; Sfriso, Adriano; Chiesa, Stefania

doi:10.1111/jzs.12386

Cited by 8 publications

(7 citation statements)

References 86 publications

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“…Therefore, adult females are generally homoplasmic for F mitochondria, while the F lineage dominates in the adult male soma but not for the male germline, which is homoplasmic for M mitochondria [32][33][34][35][36][37][38]. Nonetheless, many patterns of F and M lineage distribution are known from different DUI species [30,39]).…”

Section: Introductionmentioning

confidence: 99%

“…Using the same approach, no evidence has been found for DUI in the handful of gastropod species that have been explored [47,48]. Unfortunately, negative results are seldom published; typically, they are provided along with positive results in other species [39,43]. However, even negative results are highly valuable for achieving effective characterisation of DUI distribution.…”

Section: Introductionmentioning

confidence: 99%

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Negative Evidence for Sex-Linked Heteroplasmy in the Nemertean Worm Notospermus geniculatus (Delle Chiaje, 1822)

Santovito,

Brustenga,

Lucentini

et al. 2023

Sustainability

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Doubly Uniparental Inheritance (DUI) is considered one of the major exceptions to the common rules of eukaryotic cell biology and germline formation. DUI is known in bivalves, which belong to the phylum Mollusca; conversely, no DUI evidence was found in some gastropod species. Investigating the presence of DUI in Nemertea is of particular interest given the fact that these spiralian animals are suggested to be a sister group of Neotrochozoa (i.e., Mollusca and Annelida). DUI species are normally detected as having two sex-associated mtDNAs, which can be highly divergent. In this work, the presence of sex-associated mitochondrial genomes was investigated in the nemertean species Notospermus geniculatus and no evidence was found for DUI. Even if these are preliminary results, negative evidence is still interesting because of the high importance of the DUI phenomenon in many research fields, where it plays a pivotal role in understanding eukaryotic evolution. For this reason, further research on DUI species detection should be highly encouraged, as well as the publication of negative results beside positive ones, as is the case for the present study, improving the knowledge on the biology and ecology of a broad spectrum of marine species.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Negative Evidence for Sex-Linked Heteroplasmy in the Nemertean Worm Notospermus geniculatus (Delle Chiaje, 1822)

Santovito,

Brustenga,

Lucentini

et al. 2023

Sustainability

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“…Nevertheless, many studies suggested the presence of DUI in this genus 3 , 16 , 19 , 24 – 26 . However, there are well-known difficulties with detecting DUI by end-point PCR with universal primers 27 . The variability of the sequence divergence between mitogenome pairs ranges from around 5% to over 50% 16 , 28 , 29 .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, regardless of the divergence, there is always a possibility that a mitogenome of another, contaminating, biological entity, would be co-amplified. This is facilitated by high sensitivity of end-point PCR protocols 12 , 21 , 27 . All this prompted us to use a quantitative mitogenomic approach to further corroborate the possibility of DUI in this species.…”

Section: Introductionmentioning

confidence: 99%

No evidence of DUI in the Mediterranean alien species Brachidontes pharaonis (P. Fisher, 1870) despite mitochondrial heteroplasmy

Lubośny

Śmietanka

Arculeo

et al. 2022

Sci Rep

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Two genetically different mitochondrial haplogroups of Brachidontes pharaonis (p-distance 6.8%) have been identified in the Mediterranean Sea. This hinted at a possible presence of doubly uniparental inheritance in this species. To ascertain this possibility, we sequenced two complete mitogenomes of Brachidontes pharaonis mussels and performed a qPCR analysis to measure the relative mitogenome copy numbers of both mtDNAs. Despite the presence of two very similar regions composed entirely of repetitive sequences in the two haplogroups, no recombination between mitogenomes was detected. In heteroplasmic individuals, both mitogenomes were present in the generative tissues of both sexes, which argues against the presence of doubly uniparental inheritance in this species.

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“…There is not only one type of mtDNA in an organism, but actually, the same individual may contain two or more types of mtDNA, which is known as mitochondrial heteroplasmy [17,18]. The types of mitochondrial heteroplasmy can be classified as site heteroplasmy and length heteroplasmy, which are usually derived from somatic mutations that occur mostly in embryonic stages [19], paternal leakage, maternally transmitted heteroplasmy [20], doubly uniparental inheritance in the bivalve [21,22], etc. In Drosophila, some species (D. melanogaster, D. simulans, D. mauritian and D. subobscura) were detected to possess mitochondrial length heteroplasmy through the method of restriction digestion [23,24].…”

Section: Introductionmentioning

confidence: 99%

The gender-specific impact of starvation on mitotypes diversity in adults of Drosophila melanogaster

Wang

Miao

et al. 2022

Open Biol.

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In animals, starvation can increase the level of reactive oxygen species (ROS) in some tissues. Mitochondrial DNA (mtDNA) is more vulnerable to being attacked by ROS due to the lack of histone protection, leading to oxidative damage. However, whether starvation is associated with the genetic diversity of mtDNA remains unclear. Here, by using adult individuals of Drosophila melanogaster under three different feeding treatments (starvation, with the provision of only water, and normal feeding), based on the high-throughput sequencing results of the PCR amplicons of the partial sequences of the mitochondrial gene cytochrome c oxidase subunit I ( mt-cox1 ), no significant difference in the mean number of mitochondrial haplotypes and the mean genetic distance of haplotypes within individuals were identified between the three treatment groups. Coupled with the low proportion of heterogeneous mt-cox1 sequences within each individual, it suggested that starvation had a limited impact on mitotype genetic diversity and mitochondrial function. Nevertheless, starvation could significantly increase the sequence number of haplotypes containing specific mutations, and for males with higher levels of mitochondrial heteroplasmy than females in the normal feeding group, starvation could further increase their mitochondrial heteroplasmy.

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Additional taxonomic coverage of the doubly uniparental inheritance in bivalves: Evidence of sex‐linked heteroplasmy in the razor clam Solen marginatus Pulteney, 1799, but not in the lagoon cockle Cerastoderma glaucum (Bruguière, 1789)

Cited by 8 publications

References 86 publications

Negative Evidence for Sex-Linked Heteroplasmy in the Nemertean Worm Notospermus geniculatus (Delle Chiaje, 1822)

Negative Evidence for Sex-Linked Heteroplasmy in the Nemertean Worm Notospermus geniculatus (Delle Chiaje, 1822)

No evidence of DUI in the Mediterranean alien species Brachidontes pharaonis (P. Fisher, 1870) despite mitochondrial heteroplasmy

The gender-specific impact of starvation on mitotypes diversity in adults of Drosophila melanogaster

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