Additional value of fdg-pet in epilepsy surgery: consistency and postoperative results compared with MRI and eeg

Gökdemir, Selim; Halaç, Metin; Albayram, Sait; Öz, Büğe; Yeni, Naz; Uzan, Mustafa; Özkara, Çiğdem

doi:10.5137/1019-5149.jtn.9752-13.1

Cited by 5 publications

(43 citation statements)

References 9 publications

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“…This corroborates previously reported observations, including: (1) FDG-PET studies which have consistently highlighted a metabolic deterioration of frontal and anterior cingulate cortices with age [9,17,18] and (2) morphometric studies where a global brain atrophy was documented with age, but with a predominance in the prefrontal cortex [19], and to a lower extent in parietal, temporal and insular grey matter areas [20][21][22]. Furthermore, the relative sparing of FDG uptake in amygdalohippocampal complexes and entorhinal cortices observed in the present study are also in accordance with the findings from previous FDG-PET studies [21,[23][24][25][26].…”

Section: Discussionsupporting

confidence: 95%

See 1 more Smart Citation

Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

Gucht¹,

Verger

Guedj

et al. 2015

Ann Nucl Med

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Section: Discussionsupporting

confidence: 95%

“…Indeed, the impact of age on frontal and temporal glucose metabolism should be considered when analysing patients with possible frontal and/or temporal diseases, such as those with temporal lobe epilepsy [25], Alzheimer's disease [26], frontotemporal lobar degeneration [27] or schizophrenia [28].…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

Gucht¹,

Verger

Guedj

et al. 2015

Ann Nucl Med

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“…However, SISCOM data were not available for this study. In comparison, previous PET studies (conducted mainly in nonoperated adults) demonstrated 43–68% localization of the anatomic location of a structural lesion over MRI data …”

Section: Discussionmentioning

confidence: 64%

“…In comparison, previous PET studies (conducted mainly in nonoperated adults) demonstrated 43-68% localization of the anatomic location of a structural lesion over MRI data. [20][21][22] The localizing power of 3D-ESI in patients undergoing temporal resection was particularly significant. 3D-ESI in temporal lobe patients showed superior localizing power compared to PET and iSPECT.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic utility of 3D electroencephalography source imaging in pediatric epilepsy surgery

et al. 2015

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SUMMARYObjective: The aim of this study was to investigate the utility of three-dimensional electroencephalography source imaging (3D-ESI) with low-resolution electroencephalographic data in the pediatric noninvasive presurgical evaluation, and to compare the findings with positron emission tomography (PET) and ictal single-photon emission computed tomography (iSPECT). Methods: We retrospectively selected 60 patients from a database of 594 patients who underwent excisional surgery for drug-resistant epilepsy. Patients were <18 years at time of surgery, had at least one presurgical volumetric brain magnetic resonance imaging (MRI), and at least 1 year of outcome data. 3D-ESI was performed with NeuroScan software CURRY V.7.0. For each patient the surgical resection was planned utilizing 3D-ESI as an adjunctive tool to supplement MRI and electrocorticographic data. Our analyses addressed three critical variables: pathology (focal cortical dysplasia vs. other pathologies), imaging (MRI negative vs. positive cases), and surgery (temporal resection vs. extratemporal and multilobar resections). We also compared the localizing utility and surgical outcome of 3D-ESI findings with PET, iSPECT, and the colocalized surgical resection. Statistical analyses were performed using the Statistical Package for the Social Sciences, Version 20. Results: Mean age at surgery was 11.18 years (range 1-18 years). 3D-ESI showed a strong correlation with the surgical resection cavity (65.0%), particularly within the temporal lobe. 3D-ESI demonstrated better localization in MRI-negative cases (78.6%), which was not statistically significant. 3D-ESI also correlated with a superior surgical outcome profile compared to PET and iSPECT. Significance: Our findings demonstrate that 3D-ESI data obtained with low-resolution electroencephalography achieves reasonably accurate noninvasive localization of epileptic spikes in pediatric focal epilepsy, especially in temporal lobe and MRI-negative cases, and is comparable to iSPECT and PET. Given its lesser expense and lack of radiation exposure, 3D-ESI is a useful and efficient tool for evaluating surgical candidacy in pediatric epilepsy surgery centers, particularly if PET and iSPECT are unavailable.

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“…In der klinischen Routine findet die 18 F-FDG-PET Anwendung in der interiktalen Anfallsursprungslokalisation bei fokalen Epilepsien. Der Glukosemetabolismus wird hierbei mit einer iktalen Perfusionsuntersuchung mittels 99 m Tc-ECD oder 99 m Tc-HMPAO-SPECT korreliert, um anhand der dargestellten Abweichungen zum übrigen Kortex eine genauere Eingrenzung des Anfallsursprungs vornehmen zu können [49] (siehe ▶ Abb. 4).…”

Section: Epilepsieunclassified

Neuro-PET – ein Update

Beyer

Rominger

2018

Nuklearmediziner

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ZusammenfassungNeurologische Fragestellungen haben in der Positronen-Emissions-Tomografie seit vielen Jahren einen festen Stellenwert. In dieser Übersichtsarbeit werden in der Klinik gängige Untersuchungsmethoden bei der Demenzdiagnostik, Abklärung von Bewegungsstörungen sowie der Epilepsiediagnostik unter Berücksichtigung aktueller Leitlinien dargestellt und durch aktuelle Entwicklungen in der Wissenschaft erweitert. Ebenso wird die nuklearmedizinische Diagnostik von Hirntumoren samt theragnostischem Ausblick aufgezeigt. In einem weiteren Subkapitel wird die Entwicklung im Bereich der Neuroinflammation erläutert. Insgesamt lässt sich festhalten, dass in der Neuronuklearmedizin in den letzten Jahren einige Neuentwicklungen hervorgebracht wurden, welche sicherlich ihren Stellenwert auch in der klinischen Routine finden werden.

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Additional value of fdg-pet in epilepsy surgery: consistency and postoperative results compared with MRI and eeg

Cited by 5 publications

References 9 publications

Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

The diagnostic utility of 3D electroencephalography source imaging in pediatric epilepsy surgery

Neuro-PET – ein Update

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