Additive and antagonistic effects of substrate and vapors on self-assembly of glycyl-glycine in thin films

Зиганшин, Марат А.; Morozova, A. S.; Ziganshina, S. A.; Vorobev, V. V.; Suwińska, Kinga; Бухараев, А. А.; Gorbatchuk, Valery V.

doi:10.1080/15421406.2019.1683311

Cited by 11 publications

(2 citation statements)

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“…AFM is an important method for research in biology and pharmacology, which allows one to study the structural and mechanical properties of a broad range of biological substances and their interactions with various surfaces. In turn, this makes it possible to carry out a rational design of nanomaterials and control their structural properties. , Figure shows the surface topography of the PTFE membrane. The sizes of pores in the membrane are characterized by a polymodal distribution and vary in the range from 0.45 to 1.97 μm (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…To characterize the surface topography of a semipermeable hydrophobic membrane that was used as a model of stratum corneum 31 and evaluate the adhesion forces of LLC systems, we used atomic force microscopy. AFM is an important method for research in biology and pharmacology, which allows one to study the structural and mechanical properties of a broad range of biological substances and their interactions with various surfaces.…”

Section: Study Of Ptfe Membrane Surface Topography and Evaluation Of ...mentioning

confidence: 99%

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Pluronic P123/DMSO Lyotropic Liquid Crystal for Incorporating Bioactive Substances for Topical Application

Selivanova,

Galeeva,

Ziganshin

et al. 2024

J. Phys. Chem. B

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Lyotropic liquid crystals (LLCs) have attracted considerably growing interest in drug delivery applications over the last years. The structure of LLC matrices is complementary to cell membranes and provides an efficient, controlled, and selective release of drugs. In this work, a complex of experimental methods was used to characterize binary LLCs Pluronic P123/DMSO and triple LLC systems Pluronic P123/DMSO/Ibuprofen, which are interesting as transdermal drug delivery systems. Liquid crystalline, thermal, and rheological properties of LLCs were studied. Concentration and temperature areas of the lyomesophase existence were found, and phase transition enthalpies were evaluated. Intermolecular interactions among the components were studied by infrared (IR) spectroscopy. In vitro studies of Ibuprofen (Ibu) release from various LLCs allow differentiation of its release depending on the polymer content. Atomic force microscopy and contact angle methods were used to characterize the surface morphology of the hydrophobic membrane, which was used as a stratum corneum model, and also evaluate the adhesion work of the LLCs. A complex analysis of the results provided by these experimental methods allowed revealing correlations between the phase behavior and rheological characteristics of the LLCs and release kinetics of ibuprofen. The proposed biocompatible systems have considerable potential for a transdermal delivery of bioactive substances.

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Section: Resultsmentioning

confidence: 99%

Section: Study Of Ptfe Membrane Surface Topography and Evaluation Of ...mentioning

confidence: 99%