Additive effect of BLA GABAA receptor mechanism and (+)-MK-801 on memory retention deficit, an isobologram analysis

Khakpoor, Mitra; Nasehi, Mohammad; Vahdati, Akbar; Hoseyni, Seyed-Ebrahim; Zarrindast, Mohammad‐Reza

doi:10.1016/j.pbb.2016.02.001

Cited by 8 publications

(2 citation statements)

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“…Withdrawal scenarios can reactivate the addictive memory when the patient enters a scene that was previously associated with withdrawal symptoms ( Hellemans et al, 2006 ). According to previous studies, the basolateral amygdala (BLA) plays an important role in inducing addictive memory retrieval ( Wang et al, 2014 ; Khakpoor et al, 2016 ; Yi et al, 2021 ). However, its downstream neural circuits remain unknown.…”

Section: Optogenetic Research Methodsmentioning

confidence: 99%

The Roles of Optogenetics and Technology in Neurobiology: A Review

Chen

Liang

et al. 2022

Front. Aging Neurosci.

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Optogenetic is a technique that combines optics and genetics to control specific neurons. This technique usually uses adenoviruses that encode photosensitive protein. The adenovirus may concentrate in a specific neural region. By shining light on the target nerve region, the photosensitive protein encoded by the adenovirus is controlled. Photosensitive proteins controlled by light can selectively allow ions inside and outside the cell membrane to pass through, resulting in inhibition or activation effects. Due to the high precision and minimally invasive, optogenetics has achieved good results in many fields, especially in the field of neuron functions and neural circuits. Significant advances have also been made in the study of many clinical diseases. This review focuses on the research of optogenetics in the field of neurobiology. These include how to use optogenetics to control nerve cells, study neural circuits, and treat diseases by changing the state of neurons. We hoped that this review will give a comprehensive understanding of the progress of optogenetics in the field of neurobiology.

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Section: Optogenetic Research Methodsmentioning

confidence: 99%

The Roles of Optogenetics and Technology in Neurobiology: A Review

Chen

Liang

et al. 2022

Front. Aging Neurosci.

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“…When the triazolam-to-pregnanolone ratio is 1:30, the synergistic effect of attenuate rates of food-maintained responding (Gunter et al, 2015). The isobologram analysis showed that an additive effect but not synergistic effect between muscimol and (+)-MK-801 on memory retention deficits in the BLA (Khakpoor et al, 2016). Phenobarbital, as active modulators of GABA A receptor, showed additive interactions when it is combined with oxcarbazepine and zonisamide (Matsumura and Nakaki, 2014).…”

Section: Application Of Isobologram Analysis To Evaluate Drug Interacmentioning

confidence: 99%

Isobologram Analysis: A Comprehensive Review of Methodology and Current Research

et al. 2019

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Drug combination is a common method for clinical disease treatment. Whether the combination of drugs is reasonable often affects the result of the disease treatment. Many methods have been used to evaluate interaction between drugs to date. Isobologram analysis has been mathematically proven and widely used to evaluate drug interactions. In this paper, the principle of isobologram analysis and its application in drug interaction evaluation are summarized. The applications of the similar cotoxicity coefficient and fractional inhibitory concentration index in the evaluation of drug interaction are also reviewed. This work is expected to evaluate the effect of formulations scientifically and provide scientific judgment standards for the development of formulations and clinical drug compatibility.

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