Additive Effect of Preservative-free Sodium Hyaluronate 0.1% in Treatment of Dry Eye Syndrome With Diquafosol 3% Eye Drops

Abstract

Treatment with diquafosol 3% with preservative-free sodium hyaluronate 0.1% was more effective than diquafosol 3% monotherapy or treatment with preserved sodium hyaluronate 0.1% in dry eye syndrome. Preservative-free sodium hyaluronate 0.1% eye drops can increase the effect of diquafosol 3% in dry eye syndrome.

Efficacy and Safety of Topical 3% Diquafosol Ophthalmic Solution for the Treatment of Multifactorial Dry Eye Disease: Meta-Analysis of Randomized Clinical Trials

“…One study examined 0.9% normal saline [11] and 1 study used placebo eye drops [15]. Topical 3% diquafosol was prescribed 4 times daily [11, 13] or 6 times daily [12, 14-16, 18]. …”

Efficacy and Safety of Topical Diquafosol Ophthalmic Solution for Treatment of Dry Eye

“…36 Three studies enrolled 286, 150, and 17 patients, respectively, and only 1 eye from each patient was selected for the study. 31,33,35 No explicit explanation relating to the selection of 2 eyes was documented. Two studies that recruited 286 and 158 patients, respectively, remained unclear on the number of eyes included in the trials.…”

“…38 A total of 4 trials were performed in Japan, 31,33,34,36 3 in the United States, 32,37,38 and 1 in Korea. 35 Two studies were conducted following 2 trials each. 33,37 One study included an RCT and a non-RCT.…”

“…A total of 8 RCTs were included in this systematic review. [31][32][33][34][35][36][37][38] Details of the selection process are given in Figure 1.…”

“…In terms of selection bias, 4 of the 8 RCTs specified the methods of random sequence generation. [33][34][35][36] Two studies provided the method of allocation concealment. 33,36 Regarding performance biases (blinding of participants and personnel), 4 of the 8 included studies were double masked, 31,32,34,37 and 2 were open label, 33,35 which were judged as high risk in both performance bias and detection bias.…”