Additive effects of 19 porcine SNPs on growth rate, meat content and selection index

Abstract

A total of 306 boars (108 Large White and 198 Landrace) were genotyped for 52 candidate SNPs to determine which of the polymorphisms influence growth rate, meat content and selection index. The effects of SNPs were estimated by a mixed linear model including a random additive polygenic animal effect, fixed effects of SNPs including additive, and pairwise additive-by-additive epistases, year*season of birth, breed and RYR1 genotype. In order to estimate all possible pairwise SNP combinations without overparameterising the model a stochastic approach was adopted. A total of 1 350 replications of the model were generated, each containing five randomly selected SNPs. The final estimates of the fixed effects of the model equaled an average out of the replications. The hypothesis of a nonzero effect of SNP was tested by the Wald test. Among 4 257 estimates calculated, many significant (P<0.01), but mostly minor effects (below 1 phenotypic standard deviation) were recorded. The selected SNPs will be further investigated to determine which may be used in MAS.

Associations of fifty single nucleotide polymorphisms within candidate genes with meatness in pigs

“…On the other hand, an interaction among and within loci may also be shown in the ranking of chromosomes. Complex genetic determination of meatness has been reported by a number of authors (Kamiński et al, 2009;Srikanchai et al, 2010;Weisz et al, 2011;Fontanesi et al, 2012).…”

“…Skinner et al (2006) suggested potential associations of the gene with swine skatole levels, however this trait is not directly connected with meatness. This locus has already been recommended as potentially associated with pork traits by Kamiński et al (2009).…”

Variants in myostatin and MyoD family genes are associated with meat quality traits in Santa Inês sheep

“…No previous studies have described an association between alteration in MyF6 (also known as MRF4) and phenotypic traits in sheep. However, variants in this gene were associated with growth 50,51 and carcass 52,53 traits in pigs. In cattle, effects on growth 54 and carcass 55 traits were also reported.…”