Additive effects of plant sterols supplementation in addition to different lipid-lowering regimens

Malina, Daniela M.T.; Fonseca, Francisco Antônio Helfenstein; Barbosa, Silvio; Kasmas, Soraia H.; Machado, Valéria A.; França, Carolina Nunes; Borges, Ney Carter do Carmo; Moreno, Ronílson Agnaldo; Izar, Maria Cristina

doi:10.1016/j.jacl.2015.04.003

Cited by 21 publications

(9 citation statements)

References 42 publications

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“…Compared with baseline, atorvastatin 40 mg showed a reduction of LDL-C (22%, p < 0.05), and increased β-sitosterol, campesterol/cholesterol, and β-sitosterol/cholesterol ratios (39%, 47%, and 32%, respectively, p < 0.05); ezetimibe 10 mg reduced campesterol and campesterol/cholesterol ratio (67% and 70%, respectively, p < 0.05), while the combined therapy decreased LDL-C (38%, p < 0.05), campesterol, β-sitosterol, and campesterol/cholesterol ratio (54%, 40%, and 27%, p < 0.05). This study demonstrated that the addition of plant sterols further reduced LDL-C by ∼6.5% in the atorvastatin therapy group and 5.0% and 4.0% in the combined therapy group (p < 0.05 for all) [292].…”

Section: Statins/ezetimibe and Plant Sterolsmentioning

confidence: 60%

Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

et al. 2017

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In recent years, there has been growing interest in the possible use of nutraceuticals to improve and optimize dyslipidemia control and therapy. Based on the data from available studies, nutraceuticals might help patients obtain theraputic lipid goals and reduce cardiovascular residual risk. Some nutraceuticals have essential lipid-lowering properties confirmed in studies; some might also have possible positive effects on nonlipid cardiovascular risk factors and have been shown to improve early markers of vascular health such as endothelial function and pulse wave velocity. However, the clinical evidence supporting the use of a single lipid-lowering nutraceutical or a combination of them is largely variable and, for many of the nutraceuticals, the evidence is very limited and, therefore, often debatable. The purpose of this position paper is to provide consensus-based recommendations for the optimal use of lipid-lowering nutraceuticals to manage dyslipidemia in patients who are still not on statin therapy, patients who are on statin or combination therapy but have not achieved lipid goals, and patients with statin intolerance. This statement is intended for physicians and other healthcare professionals engaged in the diagnosis and management of patients with lipid disorders, especially in the primary care setting.

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Section: Statins/ezetimibe and Plant Sterolsmentioning

confidence: 60%

Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

et al. 2017

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“…After systematic review of the literature, 14 studies, including 15 trials, satisfied the inclusion criteria for this meta-analysis ( Fig. 1 ) 7 8 15 18 19 20 21 22 23 24 25 26 27 28 . The characteristics of the selected trials are presented in Tables 1 and 2 .…”

Section: Resultsmentioning

confidence: 99%

Effects of plant stanol or sterol-enriched diets on lipid profiles in patients treated with statins: systematic review and meta-analysis

Han

Jiao

et al. 2016

Sci Rep

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Efficacy and safety data from trials with suitable endpoints have shown that non-statin medication in combination with a statin is a potential strategy to further reduce cardiovascular events. We aimed to evaluate the overall effect of stanol- or sterol-enriched diets on serum lipid profiles in patients treated with statins by conducting a meta-analysis of randomized controlled trials (RCTs). We used the PubMed, Cochrane library and ClinicalTrials.gov databases to search for literature published up to December 2015. Trials were included in the analysis if they were RCTs evaluating the effect of plant stanols or sterols in patients under statin therapy that reported corresponding data on serum lipid profiles. We included 15 RCTs involving a total of 500 participants. Stanol- or sterol-enriched diets in combination with statins, compared with statins alone, produced significant reductions in total cholesterol of 0.30 mmol/L (95% CI −0.36 to −0.25) and low-density lipoprotein (LDL) cholesterol of 0.30 mmol/L (95% CI −0.35 to −0.25), but not in high-density lipoprotein cholesterol or triglycerides. These results persisted in the subgroup analysis. Our meta-analysis provides further evidence that stanol- or sterol-enriched diets additionally lower total cholesterol and LDL-cholesterol levels in patients treated with statins beyond that achieved by statins alone.

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“…Red yeast rice (RYR) exhibited potent effects on lowering lipid profiles in patients suffering from cardiovascular disease and dyslipidemia [ 190 , 191 , 192 ]. A study was conducted to assess a group of nutraceuticals on their lipid modifying ability; the nutraceuticals of choice were berberine, RYR and monacolin K, policosanol, and folic acid.…”

Section: Classification Of Nutraceuticals Based On Modes Of Actionmentioning

confidence: 99%

Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

et al. 2021

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Nutraceuticals are essential food constituents that provide nutritional benefits as well as medicinal effects. The benefits of these foods are due to the presence of active compounds such as carotenoids, collagen hydrolysate, and dietary fibers. Nutraceuticals have been found to positively affect cardiovascular and immune system health and have a role in infection and cancer prevention. Nutraceuticals can be categorized into different classes based on their nature and mode of action. In this review, different classifications of nutraceuticals and their potential therapeutic activity, such as anti-cancer, antioxidant, anti-inflammatory and anti-lipid activity in disease will be reviewed. Moreover, the different mechanisms of action of these products, applications, and safety upon consumers including current trends and future prospect of nutraceuticals will be included.

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Additive effects of plant sterols supplementation in addition to different lipid-lowering regimens

Cited by 21 publications

References 42 publications

Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

Effects of plant stanol or sterol-enriched diets on lipid profiles in patients treated with statins: systematic review and meta-analysis

Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

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