Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years

Ortlepp, Jan R.; Krantz, Constanze; Kimmel, Melanie; Korff, A. Von; Vesper, Katharina; Schmitz, Fabian; Mevissen, Vera; Janssens, Uwe; Franke, Andreas; Hanrath, Peter; Zerres, Klaus; Hoffmann, Rainer

doi:10.1016/j.ijcard.2005.03.004

Cited by 34 publications

(32 citation statements)

References 26 publications

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“…In hemodialysis patients, the BsmI b allele, which is part of haplotype 1, was related to increased survival (37). In addition, the b allele is associated with a lower prevalence of coronary artery disease and diabetes mellitus type 2 (12,13). These studies support the notion that haplotype 1 may be associated with survival benefit, as was shown by a tendency in this study.…”

Section: Discussionsupporting

confidence: 89%

“…Beside effects on bone metabolism, VDR polymorphisms, in particular BsmI, are associated with cardiovascular risk factors such as increased blood pressure, an unfavorable lipid profile (8,9), increased left ventricular mass in hemodialysis patients (10), and intimal medial thickening of the carotid artery (11). In addition, VDR polymorphisms have been related to an increased risk of myocardial infarction (12) and diabetes mellitus type 2 (13)(14)(15). Moreover, the FokI, GATA, BsmI, and ApaI polymorphisms are related to an increased risk and a worse prognosis of cancer, in particular prostate cancer, breast cancer, and malignant melanoma (16).…”

Section: Introductionmentioning

confidence: 99%

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Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Jongh

Lips

Rijs

et al. 2011

European Journal of Endocrinology

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Context: Vitamin D receptor (VDR) polymorphisms are associated with a variety of diseases, which may translate into an effect on mortality. Objective: To investigate the associations between VDR gene variants and mortality among older people. Design: The analyses were conducted in a population-based, prospective cohort of the Longitudinal Aging Study Amsterdam. Adequate DNA analysis was performed in 923 men and women (R65 years). We aimed to assess the associations between mortality and the VDR polymorphism FokI, three haplotypes of the Cdx2 and GATA polymorphisms, and three haplotypes of the BsmI, ApaI, and TaqI polymorphisms. Results: During the median follow-up of 10.7 years, 480 participants deceased (51%). Homozygosity for the Cdx2-GATA haplotype 1 allele was associated with a 30% higher mortality risk compared to the absence of alleles (hazard ratios (HR) 1.30, 95% confidence intervals (CI) 1.01-1.68). Adjustment for cardiovascular risk factors and 25-hydroxyvitamin D levels did not affect this HR. The number of copies of the Cdx2-GATA haplotype 1 allele was associated, although not significantly, with an increased risk of osteoporotic fractures (0 copiesZreference, HR, 95% CI: 1 copy 2.01, 0.99-4.07 and 2 copies 1.81, 0.87-4.18). After adjustment for osteoporotic fractures, homozygosity for the Cdx2-GATA haplotype 1 allele was no longer associated with higher mortality risk (HR 1.08, 95% CI 0.83-1.41).

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Jongh

Lips

Rijs

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

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“…Similarly, the relationship of VI genotype with an early onset of MI in females was reported 54 . In both studies, age limitation is in agreement with the recent hypothesis that genetic factors may have impact on MI patients with onset only before the age of 65 years 53,54 . In contrast, no association of this SNP with MI was found in Spanish or Icelandic cohorts 18,55 .…”

Section: Atherosclerosis and MIsupporting

confidence: 90%

“…The authors found that CCR2 VI/II genotypes were significantly associated with MI in patients younger than 65 years 53 . Similarly, the relationship of VI genotype with an early onset of MI in females was reported 54 .…”

Section: Atherosclerosis and MImentioning

confidence: 96%

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Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases

Navratilova¹

2006

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Screening the human serum proteome for genotype–phenotype associations: An analysis of the IL6 –174G>C polymorphism

et al. 2007

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Interleukin (IL)-6 is a circulatory, pleiotropic cytokine with multiple roles in the immune system. Both IL-6 and the IL6 -174G>C promoter polymorphism have been linked to various diseases associated with inflammation. However, the mechanism by which the polymorphism influences disease risk is unclear. We postulated that serum proteome analysis of individuals with different IL6 -174G>C genotypes would provide insight on genotype-phenotype associations of this polymorphism and its role in disease susceptibility. Serum from a random sample of control participants in an ongoing population-based case-control study of non-Hodgkin lymphoma was pooled by IL6 genotype and used to screen for the optimal SELDI-TOF MS arrays for analysis. We report differences in serum protein expression of individuals with specific genotypes based on pooled and individual sample analysis. In particular, we report an association of the -174C allele with increased apolipoprotein C-I (ApoC-I). Additionally, we corroborate previous findings of an association of the -174C allele with lower autoantibodies to heat shock protein 60 and confirm the absence of any association between the IL6 -174G>C genotype and serum IL-6 levels. This study illustrates that proteome analysis can enhance our understanding of genotype-phenotype relationships. Additional studies are needed to clarify the interaction between the IL6 -174G>C polymorphism and ApoC-I.

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Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years

Cited by 34 publications

References 26 publications

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases

Screening the human serum proteome for genotype–phenotype associations: An analysis of the IL6 –174G>C polymorphism

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