Additive Manufactured Nanocomposites for Bone Tissue Engineering Applications: an Overview

Piaia, Lya; Salmoria, Gean Vitor; Hotza, Dachamir

doi:10.1590/1980-5373-mr-2019-0487

Cited by 8 publications

(4 citation statements)

References 104 publications

(120 reference statements)

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“…In addition, they can facilitate cell colonization, with specific functional properties that enhance cell binding, proliferation, migration, and expression, among others [5][6][7]. Therefore, the materials used in the scaffolds' production must provide adequate mechanical properties, porosity, interconnectivity, and biocompatibility [8][9][10][11]. Most of the approaches to the production of scaffolds involve adding the growth factors and/or bioresorbable bioceramics, which allow a controlled cell differentiation and improved osteoconductivity [12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue engineering approach

Piaia¹,

Silva²,

Gomes³

et al. 2021

Biomed. Mater.

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Bone regeneration and natural repair are long-standing processes that can lead to uneven new tissue growth. By introducing scaffolds that can be autografts and/or allografts, tissue engineering provides new approaches to manage the major burdens involved in this process. Polymeric scaffolds allow the incorporation of bioactive agents that improve their biological and mechanical performance, making them suitable materials for bone regeneration solutions. The present work aimed to create chitosan/beta-tricalcium phosphate-based scaffolds coated with silk fibroin and evaluate their potential for bone tissue engineering. Results showed that the obtained scaffolds have porosities up to 86%, interconnectivity up to 96%, pore sizes in the range of 60–170 μm, and a stiffness ranging from 1 to 2 MPa. Furthermore, when cultured with MC3T3 cells, the scaffolds were able to form apatite crystals after 21 d; and they were able to support cell growth and proliferation up to 14 d of culture. Besides, cellular proliferation was higher on the scaffolds coated with silk. These outcomes further demonstrate that the developed structures are suitable candidates to enhance bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue engineering approach

Piaia¹,

Silva²,

Gomes³

et al. 2021

Biomed. Mater.

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“…An effective method to solve the bone tissue damage caused by natural bone defects, tumor diseases, or accidents is the use of bone scaffolds for bone repair. Therefore, developing bioactive scaffold materials is an important undertaking 1,2 . Hydroxyapatite (HA), one of the main components of bone tissue, has recently been paid increased attention in bone repair and other medical fields 3,4 .…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, developing bioactive scaffold materials is an important undertaking. 1,2 Hydroxyapatite (HA), one of the main components of bone tissue, has recently been paid increased attention in bone repair and other medical fields. 3,4 Researchers generally believe that the nutrient transfer required for cell growth and adhesion in bone stents requires intermediate connecting channels (50−1000 μm).…”

Section: Introductionmentioning

confidence: 99%

Study of falling‐down‐type DLP 3D printing technology for high‐resolution hydroxyapatite scaffolds

You

et al. 2021

Int J Applied Ceramic Tech

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In this study, a strategy to print hydroxyapatite (HA) ceramics based on fallingdown-type digital light processing (DLP) 3D printing technology with high accuracy was proposed. The monolayer curing thickness and curing broadening of the samples were compared under different conditions, and the most suitable photoinitiator for the system and optimal amount of additive dye in the slurry were obtained. The light power density and single-layer exposure time of the light source of the DLP printer were optimized, and a number of high-resolution models of HA scaffolds with an exact square-channel aperture width of 380 μm were successfully printed. The shrinkage, microstructural, and mechanical properties of the HA ceramic scaffolds were studied at different sintering temperatures. The microstructure and composition of the scaffolds were also characterized by scanning electron microscopy and X-ray diffractometry. The compressive strength and compressive modulus of HA porous scaffold were 11.61 MPa and 1.26 GPa, respectively. And the porosity of scaffold was 31.67%.

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“…However, the fabrication of customized scaffolds from these materials remains a challenge, especially in terms of patient's implant fitting. Additive manufacturing (AM) is a breakthrough technology that allowed significant progress for tissue engineering applications, and still reveals promising solutions for custom-made bone scaffolds [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Screening method for producing suitable spray-dried HA powder for SLS application

et al. 2021

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Additive Manufactured Nanocomposites for Bone Tissue Engineering Applications: an Overview

Cited by 8 publications

References 104 publications

Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue engineering approach

Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue engineering approach

Study of falling‐down‐type DLP 3D printing technology for high‐resolution hydroxyapatite scaffolds

Screening method for producing suitable spray-dried HA powder for SLS application

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