Additive manufactured polyether-ether-ketone composite scaffolds with hydroxyapatite filler and porous structure promoted the integration with soft tissue

Sun, Changning; Zhao, Huiyu; Wang, Lei; Zhang, Jinghua; Zheng, Jibao; Yang, Zijian; Huang, Lijun; Liu, Chaozong; Li, Dichen; Li, Qingchu

doi:10.1016/j.bioadv.2022.213119

Cited by 19 publications

(15 citation statements)

References 26 publications

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“…70 In addition to the excellent mechanical properties, in vivo and in vitro experiments have shown that the composite is non-cytotoxic and has higher osteogenicity and cell adhesion than pure PEEK materials. 71 Sun et al 72 found that Ca 2+ released from HA could activate the adhesion proteins FAK upon entry into the cell by increasing the level of HA the intracellular Ca 2+ concentration was increased, thus promoting the expression of adhesion proteins/genes. For the fused filament fabrication (FFF) fabricated PEEK/HA scaffolds, HA particles are evenly distributed throughout the bulk and across the surface of the native 3D printed samples.…”

Section: Bioactive Materials Modified Peekmentioning

confidence: 99%

Strategies to improve the performance of polyetheretherketone (PEEK) as orthopedic implants: from surface modification to addition of bioactive materials

Huang,

Liu,

Wang

et al. 2024

J. Mater. Chem. B

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Section: Bioactive Materials Modified Peekmentioning

confidence: 99%

Strategies to improve the performance of polyetheretherketone (PEEK) as orthopedic implants: from surface modification to addition of bioactive materials

Huang,

Liu,

Wang

et al. 2024

J. Mater. Chem. B

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“…To be specific, the bones of different people are different in structure, morphology, etc., which necessitates the customization of artificial bone substitutes. 3D printing offers benefits in the rapid manufacture of intricate and personalized structures like ribs, mandibles, skulls, and scapulae, which ideally meet clinical requirements ( Sun et al, 2022 ). For instance, the patient-specific cranial implants, the point-of-care (POC) PEEK constructs made using 3D printing technology, demonstrated excellent dimensional precision and consistency, displaying morphological resemblance that is clinically satisfactory in both fitting and contour continuity ( Sharma et al, 2021 ).…”

Section: 3d Printed Peek For Bone Reconstructionmentioning

confidence: 99%

Research progress of 3D printed poly (ether ether ketone) in the reconstruction of craniomaxillofacial bone defects

Su,

Qiao,

Xiao

et al. 2023

Front. Bioeng. Biotechnol.

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The clinical challenge of bone defects in the craniomaxillofacial region, which can lead to significant physiological dysfunction and psychological distress, persists due to the complex and unique anatomy of craniomaxillofacial bones. These critical-sized defects require the use of bone grafts or substitutes for effective reconstruction. However, current biomaterials and methods have specific limitations in meeting the clinical demands for structural reinforcement, mechanical support, exceptional biological performance, and aesthetically pleasing reconstruction of the facial structure. These drawbacks have led to a growing need for novel materials and technologies. The growing development of 3D printing can offer significant advantages to address these issues, as demonstrated by the fabrication of patient-specific bioactive constructs with controlled structural design for complex bone defects in medical applications using this technology. Poly (ether ether ketone) (PEEK), among a number of materials used, is gaining recognition as a feasible substitute for a customized structure that closely resembles natural bone. It has proven to be an excellent, conformable, and 3D-printable material with the potential to replace traditional autografts and titanium implants. However, its biological inertness poses certain limitations. Therefore, this review summarizes the distinctive features of craniomaxillofacial bones and current methods for bone reconstruction, and then focuses on the increasingly applied 3D printed PEEK constructs in this field and an update on the advanced modifications for improved mechanical properties, biological performance, and antibacterial capacity. Exploring the potential of 3D printed PEEK is expected to lead to more cost-effective, biocompatible, and personalized treatment of craniomaxillofacial bone defects in clinical applications.

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“…However, several challenges should be considered before the aforemetioned advances of the treatment's broad application, such as the poor bonding of PEEK with bone and soft tissue ( 65 ). In terms of the ESWT, several limitations should also be noted: i) ESWT has a dose-dependent efficacy but an excessive dose would lead to excessive damage, while an insufficient dose would not reach the optimal efficacy, thus finding the optimal dose is a critical issue that clinicians should consider ( 53 ); ii) its effect on other tissues and organs should be studied more extensively; and iii) the construction of ESWT equipment deserves further study.…”

Section: Prospects and Limitationsmentioning

confidence: 99%

Extracorporeal shock wave treatment for post‑surgical fracture nonunion: Insight into its mechanism, efficacy, safety and prognostic factors (Review)

Wang

Shi

2023

Exp Ther Med

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Post-surgical fracture nonunion (PSFN) represents the failure to achieve cortical continuity at radiological examination after an orthopedic operation, which causes a considerable disease burden in patients with fractures. As one of the traditional treatment modalities, surgical therapy is associated with a high fracture union rate; however, post-surgical complications are not negligible. Therefore, less invasive therapies are needed to improve the prognosis of patients with PSFN. Extracorporeal shock wave treatment (ESWT) is a noninvasive method that presents a similar efficacy profile and favorable safety profile compared with surgical treatment. However, the application and detailed mechanism of ESWT in patients with PSFN remain unclear. The present review focuses on the mechanism, efficacy, safety and prognostic factors of ESWT in patients with PSFN, aiming to provide a theoretical basis for its application and improve the prognosis of these patients.

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Additive manufactured polyether-ether-ketone composite scaffolds with hydroxyapatite filler and porous structure promoted the integration with soft tissue

Cited by 19 publications

References 26 publications

Strategies to improve the performance of polyetheretherketone (PEEK) as orthopedic implants: from surface modification to addition of bioactive materials

Strategies to improve the performance of polyetheretherketone (PEEK) as orthopedic implants: from surface modification to addition of bioactive materials

Research progress of 3D printed poly (ether ether ketone) in the reconstruction of craniomaxillofacial bone defects

Extracorporeal shock wave treatment for post‑surgical fracture nonunion: Insight into its mechanism, efficacy, safety and prognostic factors (Review)

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